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Prominent role of histone lysine demethylases in cancer epigenetics and therapy

Protein methylation has an important role in the regulation of chromatin, gene expression and regulation. The protein methyl transferases are genetically altered in various human cancers. The enzymes that remove histone methylation have led to increased awareness of protein interactions as potential...

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Autores principales: Janardhan, Avilala, Kathera, Chandrasekhar, Darsi, Amrutha, Ali, Wajid, He, Lingfeng, Yang, Yanhua, Luo, Libo, Guo, Zhigang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188137/
https://www.ncbi.nlm.nih.gov/pubmed/30344952
http://dx.doi.org/10.18632/oncotarget.24319
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author Janardhan, Avilala
Kathera, Chandrasekhar
Darsi, Amrutha
Ali, Wajid
He, Lingfeng
Yang, Yanhua
Luo, Libo
Guo, Zhigang
author_facet Janardhan, Avilala
Kathera, Chandrasekhar
Darsi, Amrutha
Ali, Wajid
He, Lingfeng
Yang, Yanhua
Luo, Libo
Guo, Zhigang
author_sort Janardhan, Avilala
collection PubMed
description Protein methylation has an important role in the regulation of chromatin, gene expression and regulation. The protein methyl transferases are genetically altered in various human cancers. The enzymes that remove histone methylation have led to increased awareness of protein interactions as potential drug targets. Specifically, Lysine Specific Demethylases (LSD) removes methylated histone H3 lysine 4 (H3K4) and H3 lysine 9 (H3K9) through formaldehyde-generating oxidation. It has been reported that LSD1 and its downstream targets are involved in tumor-cell growth and metastasis. Functional studies of LSD1 indicate that it regulates activation and inhibition of gene transcription in the nucleus. Here we made a discussion about the summary of histone lysine demethylase and their functions in various human cancers.
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spelling pubmed-61881372018-10-21 Prominent role of histone lysine demethylases in cancer epigenetics and therapy Janardhan, Avilala Kathera, Chandrasekhar Darsi, Amrutha Ali, Wajid He, Lingfeng Yang, Yanhua Luo, Libo Guo, Zhigang Oncotarget Review Protein methylation has an important role in the regulation of chromatin, gene expression and regulation. The protein methyl transferases are genetically altered in various human cancers. The enzymes that remove histone methylation have led to increased awareness of protein interactions as potential drug targets. Specifically, Lysine Specific Demethylases (LSD) removes methylated histone H3 lysine 4 (H3K4) and H3 lysine 9 (H3K9) through formaldehyde-generating oxidation. It has been reported that LSD1 and its downstream targets are involved in tumor-cell growth and metastasis. Functional studies of LSD1 indicate that it regulates activation and inhibition of gene transcription in the nucleus. Here we made a discussion about the summary of histone lysine demethylase and their functions in various human cancers. Impact Journals LLC 2018-01-25 /pmc/articles/PMC6188137/ /pubmed/30344952 http://dx.doi.org/10.18632/oncotarget.24319 Text en Copyright: © 2018 Janardhan et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (http://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Review
Janardhan, Avilala
Kathera, Chandrasekhar
Darsi, Amrutha
Ali, Wajid
He, Lingfeng
Yang, Yanhua
Luo, Libo
Guo, Zhigang
Prominent role of histone lysine demethylases in cancer epigenetics and therapy
title Prominent role of histone lysine demethylases in cancer epigenetics and therapy
title_full Prominent role of histone lysine demethylases in cancer epigenetics and therapy
title_fullStr Prominent role of histone lysine demethylases in cancer epigenetics and therapy
title_full_unstemmed Prominent role of histone lysine demethylases in cancer epigenetics and therapy
title_short Prominent role of histone lysine demethylases in cancer epigenetics and therapy
title_sort prominent role of histone lysine demethylases in cancer epigenetics and therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188137/
https://www.ncbi.nlm.nih.gov/pubmed/30344952
http://dx.doi.org/10.18632/oncotarget.24319
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