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Molecular dynamics simulation reveals the possible druggable hot-spots of USP7

The plasticity in Ubiquitin Specific Proteases (USP7) inducing conformational changes at important areas has highlighted an intricate mechanism, by which USP7 is regulated. Given the importance of USP7 in oncogenic pathways and immune-oncology, identification of USP7 inhibitors has attracted conside...

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Detalles Bibliográficos
Autores principales:	Srivastava, Mitul, Suri, Charu, Singh, Mrityunjay, Mathur, Rajani, Asthana, Shailendra
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2018
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188144/ https://www.ncbi.nlm.nih.gov/pubmed/30344943 http://dx.doi.org/10.18632/oncotarget.26136

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