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Vitamin D receptor as a marker of prognosis in oesophageal adenocarcinoma: a prospective cohort study

AIMS: Vitamin D receptor (VDR) expression has been associated with survival in several cancer sites. This study aims to evaluate the association between VDR expression and prognosis in oesophageal adenocarcinoma patients. RESULTS: During a median of 2.5 (maximum 9) years of follow-up, 75 patients di...

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Autores principales: McCain, Stephen, Trainor, James, McManus, Damian T., McMenamin, Úna C., McQuaid, Stephen, Bingham, Victoria, James, Jacqueline A., Salto-Tellez, Manuel, Turkington, Richard C., Coleman, Helen G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188147/
https://www.ncbi.nlm.nih.gov/pubmed/30344947
http://dx.doi.org/10.18632/oncotarget.26151
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author McCain, Stephen
Trainor, James
McManus, Damian T.
McMenamin, Úna C.
McQuaid, Stephen
Bingham, Victoria
James, Jacqueline A.
Salto-Tellez, Manuel
Turkington, Richard C.
Coleman, Helen G.
author_facet McCain, Stephen
Trainor, James
McManus, Damian T.
McMenamin, Úna C.
McQuaid, Stephen
Bingham, Victoria
James, Jacqueline A.
Salto-Tellez, Manuel
Turkington, Richard C.
Coleman, Helen G.
author_sort McCain, Stephen
collection PubMed
description AIMS: Vitamin D receptor (VDR) expression has been associated with survival in several cancer sites. This study aims to evaluate the association between VDR expression and prognosis in oesophageal adenocarcinoma patients. RESULTS: During a median of 2.5 (maximum 9) years of follow-up, 75 patients died. In analysis adjusted for confounders, higher VDR expression was associated with an improved overall survival (HR 0.49 95% CI 0.25–0.96) and disease-specific survival (HR 0.50 95% CI 0.26–0.99), when comparing the highest with the lowest tertile of expression. These associations were strongest in sensitivity analysis restricted to junctional tumours. CONCLUSIONS: This study is the first to demonstrate that patients with higher VDR expression in oesophageal adenocarcinoma have a more favourable prognosis. Further work is needed to validate these findings, and to define the role of VDR in the aetiology, progression and management of oesophageal adenocarcinoma. METHODS: Oesophageal adenocarcinoma specimens and clinical data were collected from 130 patients treated with neo-adjuvant chemotherapy prior to surgical resection at the Northern Ireland Cancer Centre between 2004 and 2012. Tissue microarrays were created and immunohistochemical staining for VDR was performed on triplicate tumour cores from each resection specimen. Cox proportional hazards models were applied to evaluate associations between VDR, according to tertiles of expression, and survival outcomes.
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spelling pubmed-61881472018-10-21 Vitamin D receptor as a marker of prognosis in oesophageal adenocarcinoma: a prospective cohort study McCain, Stephen Trainor, James McManus, Damian T. McMenamin, Úna C. McQuaid, Stephen Bingham, Victoria James, Jacqueline A. Salto-Tellez, Manuel Turkington, Richard C. Coleman, Helen G. Oncotarget Research Paper AIMS: Vitamin D receptor (VDR) expression has been associated with survival in several cancer sites. This study aims to evaluate the association between VDR expression and prognosis in oesophageal adenocarcinoma patients. RESULTS: During a median of 2.5 (maximum 9) years of follow-up, 75 patients died. In analysis adjusted for confounders, higher VDR expression was associated with an improved overall survival (HR 0.49 95% CI 0.25–0.96) and disease-specific survival (HR 0.50 95% CI 0.26–0.99), when comparing the highest with the lowest tertile of expression. These associations were strongest in sensitivity analysis restricted to junctional tumours. CONCLUSIONS: This study is the first to demonstrate that patients with higher VDR expression in oesophageal adenocarcinoma have a more favourable prognosis. Further work is needed to validate these findings, and to define the role of VDR in the aetiology, progression and management of oesophageal adenocarcinoma. METHODS: Oesophageal adenocarcinoma specimens and clinical data were collected from 130 patients treated with neo-adjuvant chemotherapy prior to surgical resection at the Northern Ireland Cancer Centre between 2004 and 2012. Tissue microarrays were created and immunohistochemical staining for VDR was performed on triplicate tumour cores from each resection specimen. Cox proportional hazards models were applied to evaluate associations between VDR, according to tertiles of expression, and survival outcomes. Impact Journals LLC 2018-09-28 /pmc/articles/PMC6188147/ /pubmed/30344947 http://dx.doi.org/10.18632/oncotarget.26151 Text en Copyright: © 2018 McCain et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (http://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
McCain, Stephen
Trainor, James
McManus, Damian T.
McMenamin, Úna C.
McQuaid, Stephen
Bingham, Victoria
James, Jacqueline A.
Salto-Tellez, Manuel
Turkington, Richard C.
Coleman, Helen G.
Vitamin D receptor as a marker of prognosis in oesophageal adenocarcinoma: a prospective cohort study
title Vitamin D receptor as a marker of prognosis in oesophageal adenocarcinoma: a prospective cohort study
title_full Vitamin D receptor as a marker of prognosis in oesophageal adenocarcinoma: a prospective cohort study
title_fullStr Vitamin D receptor as a marker of prognosis in oesophageal adenocarcinoma: a prospective cohort study
title_full_unstemmed Vitamin D receptor as a marker of prognosis in oesophageal adenocarcinoma: a prospective cohort study
title_short Vitamin D receptor as a marker of prognosis in oesophageal adenocarcinoma: a prospective cohort study
title_sort vitamin d receptor as a marker of prognosis in oesophageal adenocarcinoma: a prospective cohort study
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188147/
https://www.ncbi.nlm.nih.gov/pubmed/30344947
http://dx.doi.org/10.18632/oncotarget.26151
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