Neuronavigation-guided high-dose repetitive transcranial magnetic stimulation for the treatment of depressive adolescents with suicidal ideation: a case series

BACKGROUND: A high proportion of adolescents with major depressive disorder currently do not respond to conventional treatment. Repetitive transcranial magnetic stimulation (rTMS) is a promising treatment for major depressive disorder. CASE: We report on 3 cases of adolescents with suicidal ideation...

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Autores principales: Pan, Fen, Li, Da, Wang, Xiaojing, Lu, Shaojia, Xu, Yi, Huang, Manli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Case Series
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188184/
https://www.ncbi.nlm.nih.gov/pubmed/30349265
http://dx.doi.org/10.2147/NDT.S176125
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author Pan, Fen
Li, Da
Wang, Xiaojing
Lu, Shaojia
Xu, Yi
Huang, Manli
author_facet Pan, Fen
Li, Da
Wang, Xiaojing
Lu, Shaojia
Xu, Yi
Huang, Manli
author_sort Pan, Fen
collection PubMed
description BACKGROUND: A high proportion of adolescents with major depressive disorder currently do not respond to conventional treatment. Repetitive transcranial magnetic stimulation (rTMS) is a promising treatment for major depressive disorder. CASE: We report on 3 cases of adolescents with suicidal ideation receiving 7 daily 10 Hz left prefrontal rTMS combined with pharmacotherapy treatment over 1 week for major depressive episode. The left dorsolateral prefrontal cortex was identified using magnetic resonance imaging-guided neuronavigation prior to stimulation. The suicidal ideation of these patients lessened significantly following rTMS treatment. Regarding adverse effects, symptoms of hypomania occurred in two patients since day 4, but no other side effects were found. CONCLUSION: Neuronavigation-guided high-dose rTMS may be an effective and feasible treatment option for depressive adolescents with suicidal ideation. Caution over treatment-emergent mania/hypomania associated with rTMS is required.
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spelling pubmed-61881842018-10-22 Neuronavigation-guided high-dose repetitive transcranial magnetic stimulation for the treatment of depressive adolescents with suicidal ideation: a case series Pan, Fen Li, Da Wang, Xiaojing Lu, Shaojia Xu, Yi Huang, Manli Neuropsychiatr Dis Treat Case Series BACKGROUND: A high proportion of adolescents with major depressive disorder currently do not respond to conventional treatment. Repetitive transcranial magnetic stimulation (rTMS) is a promising treatment for major depressive disorder. CASE: We report on 3 cases of adolescents with suicidal ideation receiving 7 daily 10 Hz left prefrontal rTMS combined with pharmacotherapy treatment over 1 week for major depressive episode. The left dorsolateral prefrontal cortex was identified using magnetic resonance imaging-guided neuronavigation prior to stimulation. The suicidal ideation of these patients lessened significantly following rTMS treatment. Regarding adverse effects, symptoms of hypomania occurred in two patients since day 4, but no other side effects were found. CONCLUSION: Neuronavigation-guided high-dose rTMS may be an effective and feasible treatment option for depressive adolescents with suicidal ideation. Caution over treatment-emergent mania/hypomania associated with rTMS is required. Dove Medical Press 2018-10-10 /pmc/articles/PMC6188184/ /pubmed/30349265 http://dx.doi.org/10.2147/NDT.S176125 Text en © 2018 Pan et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Case Series
Pan, Fen
Li, Da
Wang, Xiaojing
Lu, Shaojia
Xu, Yi
Huang, Manli
Neuronavigation-guided high-dose repetitive transcranial magnetic stimulation for the treatment of depressive adolescents with suicidal ideation: a case series
title Neuronavigation-guided high-dose repetitive transcranial magnetic stimulation for the treatment of depressive adolescents with suicidal ideation: a case series
title_full Neuronavigation-guided high-dose repetitive transcranial magnetic stimulation for the treatment of depressive adolescents with suicidal ideation: a case series
title_fullStr Neuronavigation-guided high-dose repetitive transcranial magnetic stimulation for the treatment of depressive adolescents with suicidal ideation: a case series
title_full_unstemmed Neuronavigation-guided high-dose repetitive transcranial magnetic stimulation for the treatment of depressive adolescents with suicidal ideation: a case series
title_short Neuronavigation-guided high-dose repetitive transcranial magnetic stimulation for the treatment of depressive adolescents with suicidal ideation: a case series
title_sort neuronavigation-guided high-dose repetitive transcranial magnetic stimulation for the treatment of depressive adolescents with suicidal ideation: a case series
topic Case Series
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188184/
https://www.ncbi.nlm.nih.gov/pubmed/30349265
http://dx.doi.org/10.2147/NDT.S176125
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