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Сase Report of Acute Toxic Imatinib-induced Hepatitis in a Patient with Chronic Myeloid Leukemia, Sulfa Allergy, and Rheumatoid Arthritis

The introduction of imatinib has substantially changed the approaches to the therapy of chronic myeloid leukemia. However, this drug can cause hepatic failure and death in rare cases. This report describes a clinical case of acute, toxic imatinib-induced hepatitis in a 56-year-old woman with chronic...

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Autores principales: Lopina, Nataliia, Dyagil, Iryna, Hamov, Dmytro, Zhuravlyova, Larysa, Dmytrenko, Iryna, Lopin, Dmytro, Igor, Kuznetsov
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188217/
https://www.ncbi.nlm.nih.gov/pubmed/30345193
http://dx.doi.org/10.7759/cureus.3136
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author Lopina, Nataliia
Dyagil, Iryna
Hamov, Dmytro
Zhuravlyova, Larysa
Dmytrenko, Iryna
Lopin, Dmytro
Igor, Kuznetsov
author_facet Lopina, Nataliia
Dyagil, Iryna
Hamov, Dmytro
Zhuravlyova, Larysa
Dmytrenko, Iryna
Lopin, Dmytro
Igor, Kuznetsov
author_sort Lopina, Nataliia
collection PubMed
description The introduction of imatinib has substantially changed the approaches to the therapy of chronic myeloid leukemia. However, this drug can cause hepatic failure and death in rare cases. This report describes a clinical case of acute, toxic imatinib-induced hepatitis in a 56-year-old woman with chronic myeloid leukemia and concomitant sulfa allergy and rheumatoid arthritis. The patient developed acute imatinib-induced hepatitis after three months of treatment with imatinib and three days after increasing the imatinib dosage from 400 mg per day to 600 mg per day, resolving within three months after imatinib discontinuation and prednisolone administration. This confirms the necessity of great caution during imatinib therapy and the monitoring of liver tests. Approximately 25 reports about clinical cases of imatinib-induced hepatitis have been published up to the present.
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spelling pubmed-61882172018-10-20 Сase Report of Acute Toxic Imatinib-induced Hepatitis in a Patient with Chronic Myeloid Leukemia, Sulfa Allergy, and Rheumatoid Arthritis Lopina, Nataliia Dyagil, Iryna Hamov, Dmytro Zhuravlyova, Larysa Dmytrenko, Iryna Lopin, Dmytro Igor, Kuznetsov Cureus Internal Medicine The introduction of imatinib has substantially changed the approaches to the therapy of chronic myeloid leukemia. However, this drug can cause hepatic failure and death in rare cases. This report describes a clinical case of acute, toxic imatinib-induced hepatitis in a 56-year-old woman with chronic myeloid leukemia and concomitant sulfa allergy and rheumatoid arthritis. The patient developed acute imatinib-induced hepatitis after three months of treatment with imatinib and three days after increasing the imatinib dosage from 400 mg per day to 600 mg per day, resolving within three months after imatinib discontinuation and prednisolone administration. This confirms the necessity of great caution during imatinib therapy and the monitoring of liver tests. Approximately 25 reports about clinical cases of imatinib-induced hepatitis have been published up to the present. Cureus 2018-08-13 /pmc/articles/PMC6188217/ /pubmed/30345193 http://dx.doi.org/10.7759/cureus.3136 Text en Copyright © 2018, Lopina et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Lopina, Nataliia
Dyagil, Iryna
Hamov, Dmytro
Zhuravlyova, Larysa
Dmytrenko, Iryna
Lopin, Dmytro
Igor, Kuznetsov
Сase Report of Acute Toxic Imatinib-induced Hepatitis in a Patient with Chronic Myeloid Leukemia, Sulfa Allergy, and Rheumatoid Arthritis
title Сase Report of Acute Toxic Imatinib-induced Hepatitis in a Patient with Chronic Myeloid Leukemia, Sulfa Allergy, and Rheumatoid Arthritis
title_full Сase Report of Acute Toxic Imatinib-induced Hepatitis in a Patient with Chronic Myeloid Leukemia, Sulfa Allergy, and Rheumatoid Arthritis
title_fullStr Сase Report of Acute Toxic Imatinib-induced Hepatitis in a Patient with Chronic Myeloid Leukemia, Sulfa Allergy, and Rheumatoid Arthritis
title_full_unstemmed Сase Report of Acute Toxic Imatinib-induced Hepatitis in a Patient with Chronic Myeloid Leukemia, Sulfa Allergy, and Rheumatoid Arthritis
title_short Сase Report of Acute Toxic Imatinib-induced Hepatitis in a Patient with Chronic Myeloid Leukemia, Sulfa Allergy, and Rheumatoid Arthritis
title_sort сase report of acute toxic imatinib-induced hepatitis in a patient with chronic myeloid leukemia, sulfa allergy, and rheumatoid arthritis
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188217/
https://www.ncbi.nlm.nih.gov/pubmed/30345193
http://dx.doi.org/10.7759/cureus.3136
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