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Сase Report of Acute Toxic Imatinib-induced Hepatitis in a Patient with Chronic Myeloid Leukemia, Sulfa Allergy, and Rheumatoid Arthritis
The introduction of imatinib has substantially changed the approaches to the therapy of chronic myeloid leukemia. However, this drug can cause hepatic failure and death in rare cases. This report describes a clinical case of acute, toxic imatinib-induced hepatitis in a 56-year-old woman with chronic...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188217/ https://www.ncbi.nlm.nih.gov/pubmed/30345193 http://dx.doi.org/10.7759/cureus.3136 |
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author | Lopina, Nataliia Dyagil, Iryna Hamov, Dmytro Zhuravlyova, Larysa Dmytrenko, Iryna Lopin, Dmytro Igor, Kuznetsov |
author_facet | Lopina, Nataliia Dyagil, Iryna Hamov, Dmytro Zhuravlyova, Larysa Dmytrenko, Iryna Lopin, Dmytro Igor, Kuznetsov |
author_sort | Lopina, Nataliia |
collection | PubMed |
description | The introduction of imatinib has substantially changed the approaches to the therapy of chronic myeloid leukemia. However, this drug can cause hepatic failure and death in rare cases. This report describes a clinical case of acute, toxic imatinib-induced hepatitis in a 56-year-old woman with chronic myeloid leukemia and concomitant sulfa allergy and rheumatoid arthritis. The patient developed acute imatinib-induced hepatitis after three months of treatment with imatinib and three days after increasing the imatinib dosage from 400 mg per day to 600 mg per day, resolving within three months after imatinib discontinuation and prednisolone administration. This confirms the necessity of great caution during imatinib therapy and the monitoring of liver tests. Approximately 25 reports about clinical cases of imatinib-induced hepatitis have been published up to the present. |
format | Online Article Text |
id | pubmed-6188217 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-61882172018-10-20 Сase Report of Acute Toxic Imatinib-induced Hepatitis in a Patient with Chronic Myeloid Leukemia, Sulfa Allergy, and Rheumatoid Arthritis Lopina, Nataliia Dyagil, Iryna Hamov, Dmytro Zhuravlyova, Larysa Dmytrenko, Iryna Lopin, Dmytro Igor, Kuznetsov Cureus Internal Medicine The introduction of imatinib has substantially changed the approaches to the therapy of chronic myeloid leukemia. However, this drug can cause hepatic failure and death in rare cases. This report describes a clinical case of acute, toxic imatinib-induced hepatitis in a 56-year-old woman with chronic myeloid leukemia and concomitant sulfa allergy and rheumatoid arthritis. The patient developed acute imatinib-induced hepatitis after three months of treatment with imatinib and three days after increasing the imatinib dosage from 400 mg per day to 600 mg per day, resolving within three months after imatinib discontinuation and prednisolone administration. This confirms the necessity of great caution during imatinib therapy and the monitoring of liver tests. Approximately 25 reports about clinical cases of imatinib-induced hepatitis have been published up to the present. Cureus 2018-08-13 /pmc/articles/PMC6188217/ /pubmed/30345193 http://dx.doi.org/10.7759/cureus.3136 Text en Copyright © 2018, Lopina et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Internal Medicine Lopina, Nataliia Dyagil, Iryna Hamov, Dmytro Zhuravlyova, Larysa Dmytrenko, Iryna Lopin, Dmytro Igor, Kuznetsov Сase Report of Acute Toxic Imatinib-induced Hepatitis in a Patient with Chronic Myeloid Leukemia, Sulfa Allergy, and Rheumatoid Arthritis |
title | Сase Report of Acute Toxic Imatinib-induced Hepatitis in a Patient with Chronic Myeloid Leukemia, Sulfa Allergy, and Rheumatoid Arthritis |
title_full | Сase Report of Acute Toxic Imatinib-induced Hepatitis in a Patient with Chronic Myeloid Leukemia, Sulfa Allergy, and Rheumatoid Arthritis |
title_fullStr | Сase Report of Acute Toxic Imatinib-induced Hepatitis in a Patient with Chronic Myeloid Leukemia, Sulfa Allergy, and Rheumatoid Arthritis |
title_full_unstemmed | Сase Report of Acute Toxic Imatinib-induced Hepatitis in a Patient with Chronic Myeloid Leukemia, Sulfa Allergy, and Rheumatoid Arthritis |
title_short | Сase Report of Acute Toxic Imatinib-induced Hepatitis in a Patient with Chronic Myeloid Leukemia, Sulfa Allergy, and Rheumatoid Arthritis |
title_sort | сase report of acute toxic imatinib-induced hepatitis in a patient with chronic myeloid leukemia, sulfa allergy, and rheumatoid arthritis |
topic | Internal Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188217/ https://www.ncbi.nlm.nih.gov/pubmed/30345193 http://dx.doi.org/10.7759/cureus.3136 |
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