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Phosphodiesterase 4 inhibitor activates AMPK-SIRT6 pathway to prevent aging-related adipose deposition induced by metabolic disorder
Rolipram is a selective phosphodiesterase 4 (PDE4) inhibitor that exerts a variety of effects, including anti-inflammatory, immunosuppressive, and anti-tumor effects. The aim of this study was to investigate the effect of rolipram on metabolic disorder and its underlying mechanisms. Metabolic disord...
Autores principales: | Wang, Zhuoran, Liang, Yaru, Zhang, Lu, Zhang, Nannan, Liu, Qingfei, Wang, Zhao |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188481/ https://www.ncbi.nlm.nih.gov/pubmed/30227388 http://dx.doi.org/10.18632/aging.101559 |
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