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Targeting mitochondrial phenotypes for non-communicable diseases

The concept that “Exercise is Medicine” has been challenged by the rising prevalence of non-communicable chronic diseases (NCDs). This is partly due to the fact that the underlying mechanisms of how exercise influences energy homeostasis and counteracts high-fat diets and physical inactivity is comp...

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Autores principales: Qi, Zhengtang, Ding, Shuzhe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shanghai University of Sport 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188743/
https://www.ncbi.nlm.nih.gov/pubmed/30356553
http://dx.doi.org/10.1016/j.jshs.2016.04.002
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author Qi, Zhengtang
Ding, Shuzhe
author_facet Qi, Zhengtang
Ding, Shuzhe
author_sort Qi, Zhengtang
collection PubMed
description The concept that “Exercise is Medicine” has been challenged by the rising prevalence of non-communicable chronic diseases (NCDs). This is partly due to the fact that the underlying mechanisms of how exercise influences energy homeostasis and counteracts high-fat diets and physical inactivity is complex and remains relatively poorly understood on a molecular level. In addition to genetic polymorphisms in humans that lead to gross variations in responsiveness to exercise, adaptation in mitochondrial networks is central to physical activity, inactivity, and diet. To harness the benefits of exercise for NCDs, much work still needs to be done to improve health effectively on a societal level such as developing personalized exercise interventions aided by advances in high-throughput genomics, proteomics, and metabolomics. We propose that understanding the mitochondrial phenotype according to the molecular information of genotypes, lifestyles, and exercise responsiveness in individuals will optimize exercise effects for prevention of NCDs.
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spelling pubmed-61887432018-10-23 Targeting mitochondrial phenotypes for non-communicable diseases Qi, Zhengtang Ding, Shuzhe J Sport Health Sci Special issue on "Physical activity continuum throughout the lifespan: is exercise a medicine or what?" The concept that “Exercise is Medicine” has been challenged by the rising prevalence of non-communicable chronic diseases (NCDs). This is partly due to the fact that the underlying mechanisms of how exercise influences energy homeostasis and counteracts high-fat diets and physical inactivity is complex and remains relatively poorly understood on a molecular level. In addition to genetic polymorphisms in humans that lead to gross variations in responsiveness to exercise, adaptation in mitochondrial networks is central to physical activity, inactivity, and diet. To harness the benefits of exercise for NCDs, much work still needs to be done to improve health effectively on a societal level such as developing personalized exercise interventions aided by advances in high-throughput genomics, proteomics, and metabolomics. We propose that understanding the mitochondrial phenotype according to the molecular information of genotypes, lifestyles, and exercise responsiveness in individuals will optimize exercise effects for prevention of NCDs. Shanghai University of Sport 2016-06 2016-04-07 /pmc/articles/PMC6188743/ /pubmed/30356553 http://dx.doi.org/10.1016/j.jshs.2016.04.002 Text en © 2016 Production and hosting by Elsevier B.V. on behalf of Shanghai University of Sport. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Special issue on "Physical activity continuum throughout the lifespan: is exercise a medicine or what?"
Qi, Zhengtang
Ding, Shuzhe
Targeting mitochondrial phenotypes for non-communicable diseases
title Targeting mitochondrial phenotypes for non-communicable diseases
title_full Targeting mitochondrial phenotypes for non-communicable diseases
title_fullStr Targeting mitochondrial phenotypes for non-communicable diseases
title_full_unstemmed Targeting mitochondrial phenotypes for non-communicable diseases
title_short Targeting mitochondrial phenotypes for non-communicable diseases
title_sort targeting mitochondrial phenotypes for non-communicable diseases
topic Special issue on "Physical activity continuum throughout the lifespan: is exercise a medicine or what?"
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188743/
https://www.ncbi.nlm.nih.gov/pubmed/30356553
http://dx.doi.org/10.1016/j.jshs.2016.04.002
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