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Current Role of Chemotherapy in Nonmetastatic Nasopharyngeal Cancer

Nasopharyngeal carcinoma is highly radio- and chemosensitive tumor with its unique clinical and biological behavior. Treatment of stage I disease is radical radiotherapy alone. For stage II disease treatment is radiotherapy with or without chemotherapy. The standard of care for locally advanced naso...

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Autores principales: Bhattacharyya, Tapesh, Babu, Geethu, Kainickal, Cessal Thommachan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188855/
https://www.ncbi.nlm.nih.gov/pubmed/30364069
http://dx.doi.org/10.1155/2018/3725837
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author Bhattacharyya, Tapesh
Babu, Geethu
Kainickal, Cessal Thommachan
author_facet Bhattacharyya, Tapesh
Babu, Geethu
Kainickal, Cessal Thommachan
author_sort Bhattacharyya, Tapesh
collection PubMed
description Nasopharyngeal carcinoma is highly radio- and chemosensitive tumor with its unique clinical and biological behavior. Treatment of stage I disease is radical radiotherapy alone. For stage II disease treatment is radiotherapy with or without chemotherapy. The standard of care for locally advanced nasopharyngeal cancer (stages III-IVB) is concurrent chemoradiation. Optimum timing and sequence of chemotherapy are not yet well-defined. The role of adjuvant and induction chemotherapy is debatable. Here we are going to highlight the role of chemotherapy in nasopharyngeal carcinoma, its benefit, and controversies regarding timing and sequences.
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spelling pubmed-61888552018-10-25 Current Role of Chemotherapy in Nonmetastatic Nasopharyngeal Cancer Bhattacharyya, Tapesh Babu, Geethu Kainickal, Cessal Thommachan J Oncol Review Article Nasopharyngeal carcinoma is highly radio- and chemosensitive tumor with its unique clinical and biological behavior. Treatment of stage I disease is radical radiotherapy alone. For stage II disease treatment is radiotherapy with or without chemotherapy. The standard of care for locally advanced nasopharyngeal cancer (stages III-IVB) is concurrent chemoradiation. Optimum timing and sequence of chemotherapy are not yet well-defined. The role of adjuvant and induction chemotherapy is debatable. Here we are going to highlight the role of chemotherapy in nasopharyngeal carcinoma, its benefit, and controversies regarding timing and sequences. Hindawi 2018-10-01 /pmc/articles/PMC6188855/ /pubmed/30364069 http://dx.doi.org/10.1155/2018/3725837 Text en Copyright © 2018 Tapesh Bhattacharyya et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Bhattacharyya, Tapesh
Babu, Geethu
Kainickal, Cessal Thommachan
Current Role of Chemotherapy in Nonmetastatic Nasopharyngeal Cancer
title Current Role of Chemotherapy in Nonmetastatic Nasopharyngeal Cancer
title_full Current Role of Chemotherapy in Nonmetastatic Nasopharyngeal Cancer
title_fullStr Current Role of Chemotherapy in Nonmetastatic Nasopharyngeal Cancer
title_full_unstemmed Current Role of Chemotherapy in Nonmetastatic Nasopharyngeal Cancer
title_short Current Role of Chemotherapy in Nonmetastatic Nasopharyngeal Cancer
title_sort current role of chemotherapy in nonmetastatic nasopharyngeal cancer
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188855/
https://www.ncbi.nlm.nih.gov/pubmed/30364069
http://dx.doi.org/10.1155/2018/3725837
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