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Long Noncoding RNA LOC441178 Reduces the Invasion and Migration of Squamous Carcinoma Cells by Targeting ROCK1

In recent years, long noncoding RNAs (lncRNAs) have been reported to have significant regulating effect in human cancer development. Previous studies suggested that dysregulation of lncRNA 441178 (LOC441178) is possibly associated with oral squamous cell carcinoma (OSCC). The postoperative survival...

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Autores principales: Xu, Kai, Tian, Hurong, Zhao, Shouyong, Yuan, Daoying, Jiang, Licheng, Liu, Xianbin, Zou, Bo, Zhang, Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188856/
https://www.ncbi.nlm.nih.gov/pubmed/30364063
http://dx.doi.org/10.1155/2018/4357647
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author Xu, Kai
Tian, Hurong
Zhao, Shouyong
Yuan, Daoying
Jiang, Licheng
Liu, Xianbin
Zou, Bo
Zhang, Jin
author_facet Xu, Kai
Tian, Hurong
Zhao, Shouyong
Yuan, Daoying
Jiang, Licheng
Liu, Xianbin
Zou, Bo
Zhang, Jin
author_sort Xu, Kai
collection PubMed
description In recent years, long noncoding RNAs (lncRNAs) have been reported to have significant regulating effect in human cancer development. Previous studies suggested that dysregulation of lncRNA 441178 (LOC441178) is possibly associated with oral squamous cell carcinoma (OSCC). The postoperative survival time was significantly prolonged in the high-grade OSCC patients with high LOC441178 expression compared with those with low LOC441178 expression, which indicated that LOC441178 may act as a prognostic marker and as a potential tumor suppressor for OSCC. However, the biological molecular mechanisms behind these phenomena remain almost unknown. Here, our studies revealed that LOC441178 suppressed the invasion and migration of squamous carcinoma cells (SCCs). Furthermore, we found that rho-associated, coiled-coil-containing protein kinase 1 (ROCK1) is one of the functionally relevant targets of LOC441178 in squamous cells, which is negatively correlated with LOC441178 in tumor tissues from OSCC patients. In conclusion, our findings demonstrated the inhibition effect of LOC441178 on tumor in OSCC and might have potential implications for OSCC gene therapy. In conclusion, these results suggest that LOC441178 could represent a prognostic indicator for OSCC and be a new target for the diagnosis and treatment of OSCC.
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spelling pubmed-61888562018-10-25 Long Noncoding RNA LOC441178 Reduces the Invasion and Migration of Squamous Carcinoma Cells by Targeting ROCK1 Xu, Kai Tian, Hurong Zhao, Shouyong Yuan, Daoying Jiang, Licheng Liu, Xianbin Zou, Bo Zhang, Jin Biomed Res Int Research Article In recent years, long noncoding RNAs (lncRNAs) have been reported to have significant regulating effect in human cancer development. Previous studies suggested that dysregulation of lncRNA 441178 (LOC441178) is possibly associated with oral squamous cell carcinoma (OSCC). The postoperative survival time was significantly prolonged in the high-grade OSCC patients with high LOC441178 expression compared with those with low LOC441178 expression, which indicated that LOC441178 may act as a prognostic marker and as a potential tumor suppressor for OSCC. However, the biological molecular mechanisms behind these phenomena remain almost unknown. Here, our studies revealed that LOC441178 suppressed the invasion and migration of squamous carcinoma cells (SCCs). Furthermore, we found that rho-associated, coiled-coil-containing protein kinase 1 (ROCK1) is one of the functionally relevant targets of LOC441178 in squamous cells, which is negatively correlated with LOC441178 in tumor tissues from OSCC patients. In conclusion, our findings demonstrated the inhibition effect of LOC441178 on tumor in OSCC and might have potential implications for OSCC gene therapy. In conclusion, these results suggest that LOC441178 could represent a prognostic indicator for OSCC and be a new target for the diagnosis and treatment of OSCC. Hindawi 2018-10-01 /pmc/articles/PMC6188856/ /pubmed/30364063 http://dx.doi.org/10.1155/2018/4357647 Text en Copyright © 2018 Kai Xu et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Xu, Kai
Tian, Hurong
Zhao, Shouyong
Yuan, Daoying
Jiang, Licheng
Liu, Xianbin
Zou, Bo
Zhang, Jin
Long Noncoding RNA LOC441178 Reduces the Invasion and Migration of Squamous Carcinoma Cells by Targeting ROCK1
title Long Noncoding RNA LOC441178 Reduces the Invasion and Migration of Squamous Carcinoma Cells by Targeting ROCK1
title_full Long Noncoding RNA LOC441178 Reduces the Invasion and Migration of Squamous Carcinoma Cells by Targeting ROCK1
title_fullStr Long Noncoding RNA LOC441178 Reduces the Invasion and Migration of Squamous Carcinoma Cells by Targeting ROCK1
title_full_unstemmed Long Noncoding RNA LOC441178 Reduces the Invasion and Migration of Squamous Carcinoma Cells by Targeting ROCK1
title_short Long Noncoding RNA LOC441178 Reduces the Invasion and Migration of Squamous Carcinoma Cells by Targeting ROCK1
title_sort long noncoding rna loc441178 reduces the invasion and migration of squamous carcinoma cells by targeting rock1
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188856/
https://www.ncbi.nlm.nih.gov/pubmed/30364063
http://dx.doi.org/10.1155/2018/4357647
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