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Age-dependent impact of the SYNTAX-score on longer-term mortality after percutaneous coronary intervention in an all-comer population

BACKGROUND: The Synergy between Percutaneous Coronary Intervention with TAXUS and Cardiac Surgery (SYNTAX)-score is a validated tool for risk stratification and revascularization strategy selection in patients with complex coronary artery disease. The aim of this study was to analyse its age-related...

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Autores principales: Eickhoff, Madeleine, Schüpke, Stefanie, Khandoga, Alexander, Fabian, Julia, Baquet, Moritz, Jochheim, David, Grundmann, David, Thienel, Manuela, Bauer, Axel, Theiss, Hans, Brunner, Stefan, Hausleiter, Jörg, Massberg, Steffen, Mehilli, Julinda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Science Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188979/
https://www.ncbi.nlm.nih.gov/pubmed/30344539
http://dx.doi.org/10.11909/j.issn.1671-5411.2018.09.009
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author Eickhoff, Madeleine
Schüpke, Stefanie
Khandoga, Alexander
Fabian, Julia
Baquet, Moritz
Jochheim, David
Grundmann, David
Thienel, Manuela
Bauer, Axel
Theiss, Hans
Brunner, Stefan
Hausleiter, Jörg
Massberg, Steffen
Mehilli, Julinda
author_facet Eickhoff, Madeleine
Schüpke, Stefanie
Khandoga, Alexander
Fabian, Julia
Baquet, Moritz
Jochheim, David
Grundmann, David
Thienel, Manuela
Bauer, Axel
Theiss, Hans
Brunner, Stefan
Hausleiter, Jörg
Massberg, Steffen
Mehilli, Julinda
author_sort Eickhoff, Madeleine
collection PubMed
description BACKGROUND: The Synergy between Percutaneous Coronary Intervention with TAXUS and Cardiac Surgery (SYNTAX)-score is a validated tool for risk stratification and revascularization strategy selection in patients with complex coronary artery disease. The aim of this study was to analyse its age-related prognostic value. METHODS: SYNTAX-score was calculated in 1331 all-comer patients undergoing percutaneous coronary intervention (PCI): 463 patients ≥ 75 years and 868 patients < 75 years. Outcomes of interest were all-cause mortality at one and two years. RESULTS: A significant interaction of age and SYNTAX-score for mortality was observed at two-year (P(interaction) = 0.019) but not at one-year follow-up (P(interaction) = 0.594). In multivariable analysis, SYNTAX-score independently predicted 1-year mortality in both age groups (< 75 years, hazard ratio (HR): 1.43, 95% confidence intervals (CI): 1.03–2.00, P = 0.034; and ≥ 75 years, HR: 1.37, 95% CI: 1.01–1.85, P = 0.042), but only two-year mortality among younger patients (< 75 years, HR: 1.33, 95% CI: 1.01–1.76, P = 0.041; and ≥ 75 years, HR: 1.11, 95% CI: 0.87–1.41, P = 0.394). SYNTAX-score tertiles were useful to stratify 1-year mortality in both, patients < 75 years (SYNTAX-score < 9, 3.8%; 9–20, 5.3%; ≥ 20, 10.3%; P = 0.004) and ≥ 75 years (SYNTAX-score < 11, 5.7%; 11–22.5, 16.1%; ≥ 22.5, 18.7%; P = 0.003), but two-year mortality only among patients < 75 years (SYNTAX-score < 9, 6.5%; 9–20, 7.6%; ≥ 20, 15%; P < 0.001) and not among ≥ 75 years old patients (SYNTAX-score < 11, 19.4%; 11–22.5, 26.3%; ≥ 22.5, 27.9%; P = 0.138). CONCLUSIONS: Age modifies the impact of the SYNTAX-score on longer-term mortality after PCI. Among patients < 75 years, the SYNTAX-score independently predicts the risk of death at one and two years after PCI, while among patients ≥ 75 years its predictive role is limited to the first year after PCI. Further studies are needed to evaluate the value of SYNTAX-score for selecting the most appropriate revascularization strategy among elderly patients.
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spelling pubmed-61889792018-10-19 Age-dependent impact of the SYNTAX-score on longer-term mortality after percutaneous coronary intervention in an all-comer population Eickhoff, Madeleine Schüpke, Stefanie Khandoga, Alexander Fabian, Julia Baquet, Moritz Jochheim, David Grundmann, David Thienel, Manuela Bauer, Axel Theiss, Hans Brunner, Stefan Hausleiter, Jörg Massberg, Steffen Mehilli, Julinda J Geriatr Cardiol Research Article BACKGROUND: The Synergy between Percutaneous Coronary Intervention with TAXUS and Cardiac Surgery (SYNTAX)-score is a validated tool for risk stratification and revascularization strategy selection in patients with complex coronary artery disease. The aim of this study was to analyse its age-related prognostic value. METHODS: SYNTAX-score was calculated in 1331 all-comer patients undergoing percutaneous coronary intervention (PCI): 463 patients ≥ 75 years and 868 patients < 75 years. Outcomes of interest were all-cause mortality at one and two years. RESULTS: A significant interaction of age and SYNTAX-score for mortality was observed at two-year (P(interaction) = 0.019) but not at one-year follow-up (P(interaction) = 0.594). In multivariable analysis, SYNTAX-score independently predicted 1-year mortality in both age groups (< 75 years, hazard ratio (HR): 1.43, 95% confidence intervals (CI): 1.03–2.00, P = 0.034; and ≥ 75 years, HR: 1.37, 95% CI: 1.01–1.85, P = 0.042), but only two-year mortality among younger patients (< 75 years, HR: 1.33, 95% CI: 1.01–1.76, P = 0.041; and ≥ 75 years, HR: 1.11, 95% CI: 0.87–1.41, P = 0.394). SYNTAX-score tertiles were useful to stratify 1-year mortality in both, patients < 75 years (SYNTAX-score < 9, 3.8%; 9–20, 5.3%; ≥ 20, 10.3%; P = 0.004) and ≥ 75 years (SYNTAX-score < 11, 5.7%; 11–22.5, 16.1%; ≥ 22.5, 18.7%; P = 0.003), but two-year mortality only among patients < 75 years (SYNTAX-score < 9, 6.5%; 9–20, 7.6%; ≥ 20, 15%; P < 0.001) and not among ≥ 75 years old patients (SYNTAX-score < 11, 19.4%; 11–22.5, 26.3%; ≥ 22.5, 27.9%; P = 0.138). CONCLUSIONS: Age modifies the impact of the SYNTAX-score on longer-term mortality after PCI. Among patients < 75 years, the SYNTAX-score independently predicts the risk of death at one and two years after PCI, while among patients ≥ 75 years its predictive role is limited to the first year after PCI. Further studies are needed to evaluate the value of SYNTAX-score for selecting the most appropriate revascularization strategy among elderly patients. Science Press 2018-09-28 /pmc/articles/PMC6188979/ /pubmed/30344539 http://dx.doi.org/10.11909/j.issn.1671-5411.2018.09.009 Text en Institute of Geriatric Cardiology http://creativecommons.org/licenses/by-nc-sa/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License, which allows readers to alter, transform, or build upon the article and then distribute the resulting work under the same or similar license to this one. The work must be attributed back to the original author and commercial use is not permitted without specific permission.
spellingShingle Research Article
Eickhoff, Madeleine
Schüpke, Stefanie
Khandoga, Alexander
Fabian, Julia
Baquet, Moritz
Jochheim, David
Grundmann, David
Thienel, Manuela
Bauer, Axel
Theiss, Hans
Brunner, Stefan
Hausleiter, Jörg
Massberg, Steffen
Mehilli, Julinda
Age-dependent impact of the SYNTAX-score on longer-term mortality after percutaneous coronary intervention in an all-comer population
title Age-dependent impact of the SYNTAX-score on longer-term mortality after percutaneous coronary intervention in an all-comer population
title_full Age-dependent impact of the SYNTAX-score on longer-term mortality after percutaneous coronary intervention in an all-comer population
title_fullStr Age-dependent impact of the SYNTAX-score on longer-term mortality after percutaneous coronary intervention in an all-comer population
title_full_unstemmed Age-dependent impact of the SYNTAX-score on longer-term mortality after percutaneous coronary intervention in an all-comer population
title_short Age-dependent impact of the SYNTAX-score on longer-term mortality after percutaneous coronary intervention in an all-comer population
title_sort age-dependent impact of the syntax-score on longer-term mortality after percutaneous coronary intervention in an all-comer population
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188979/
https://www.ncbi.nlm.nih.gov/pubmed/30344539
http://dx.doi.org/10.11909/j.issn.1671-5411.2018.09.009
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