CRISPR knockout screening identifies combinatorial drug targets in pancreatic cancer and models cellular drug response

Predicting the response and identifying additional targets that will improve the efficacy of chemotherapy is a major goal in cancer research. Through large-scale in vivo and in vitro CRISPR knockout screens in pancreatic ductal adenocarcinoma cells, we identified genes whose genetic deletion or phar...

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Detalles Bibliográficos
Autores principales: Szlachta, Karol, Kuscu, Cem, Tufan, Turan, Adair, Sara J., Shang, Stephen, Michaels, Alex D., Mullen, Matthew G., Fischer, Natasha Lopes, Yang, Jiekun, Liu, Limin, Trivedi, Prasad, Stelow, Edward B., Stukenberg, P. Todd, Parsons, J. Thomas, Bauer, Todd W., Adli, Mazhar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189038/
https://www.ncbi.nlm.nih.gov/pubmed/30323222
http://dx.doi.org/10.1038/s41467-018-06676-2

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