Mrp1 is involved in lipid presentation and iNKT cell activation by Streptococcus pneumoniae

Invariant natural killer T cells (iNKT cells) are activated by lipid antigens presented by CD1d, but the pathway leading to lipid antigen presentation remains incompletely characterized. Here we show a whole-genome siRNA screen to elucidate the CD1d presentation pathway. A majority of gene knockdown...

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Detalles Bibliográficos
Autores principales: Chandra, Shilpi, Gray, James, Kiosses, William B., Khurana, Archana, Hitomi, Kaori, Crosby, Catherine M., Chawla, Ashu, Fu, Zheng, Zhao, Meng, Veerapen, Natacha, Richardson, Stewart K., Porcelli, Steven A., Besra, Gurdyal, Howell, Amy R., Sharma, Sonia, Peters, Bjoern, Kronenberg, Mitchell
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189046/
https://www.ncbi.nlm.nih.gov/pubmed/30323255
http://dx.doi.org/10.1038/s41467-018-06646-8

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