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Photo-catalytic Killing of HeLa Cancer Cells Using Facile Synthesized Pure and Ag Loaded WO(3) Nanoparticles
Chemotherapy, the most commonly used therapeutic method for cancer, has the inherent constraint of low bioavailability. A number of physical cancer therapeutic treatments like radiation, ultrasound, photo-acoustic/photo thermal, microwave therapies are based on locating the afflicted sites with the...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189059/ https://www.ncbi.nlm.nih.gov/pubmed/30323306 http://dx.doi.org/10.1038/s41598-018-33434-7 |
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author | AbuMousa, Rasha A. Baig, Umair Gondal, Mohammed A. AlSalhi, Mohamad S. Alqahtani, Fulwah Yahya Akhtar, Sultan Aleanizy, Fadilah Sfouq Dastageer, Mohamed A. |
author_facet | AbuMousa, Rasha A. Baig, Umair Gondal, Mohammed A. AlSalhi, Mohamad S. Alqahtani, Fulwah Yahya Akhtar, Sultan Aleanizy, Fadilah Sfouq Dastageer, Mohamed A. |
author_sort | AbuMousa, Rasha A. |
collection | PubMed |
description | Chemotherapy, the most commonly used therapeutic method for cancer, has the inherent constraint of low bioavailability. A number of physical cancer therapeutic treatments like radiation, ultrasound, photo-acoustic/photo thermal, microwave therapies are based on locating the afflicted sites with the help of imaging, but the serious drawbacks of these treatment options are that they damage the neighboring normal tissues and/or induce undesired cancer metastasis. In addition, these methods of treatment are very expensive and not in the reach of a common man especially in the developing countries. Therefore, innovative, less invasive and cost effective treatment methods with the help of less toxic drugs have been sought for treating cancer. In this work, photo-catalytic method of killing cancer cells, using the nanostructured silver loaded tungsten oxide (Ag/WO(3)) as photo-catalysts, in conjunction with broadband UV radiation is presented. Ag/WO(3)with two different mass ratios of Ag and WO(3) (1% Ag/WO(3) and 3% Ag/WO(3)) were synthesized, characterized and these nanostructured materials served as photo-catalysts in the process of killing cancer cells by photo-catalytic method. The advantage of loading Ag in WO(3) is quite evident from the observed increase in the photo-catalytic killing of the HeLa cells. This photo-catalytic enhancement was effectively caused by the development of Schottky junction between Ag in WO(3), which led to a substantial inhibition of photo-generated charge recombination and also by the stimulation of surface plasmon resonance in silver nanoparticles, which led to the enhanced visible light absorption by the material. |
format | Online Article Text |
id | pubmed-6189059 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-61890592018-10-22 Photo-catalytic Killing of HeLa Cancer Cells Using Facile Synthesized Pure and Ag Loaded WO(3) Nanoparticles AbuMousa, Rasha A. Baig, Umair Gondal, Mohammed A. AlSalhi, Mohamad S. Alqahtani, Fulwah Yahya Akhtar, Sultan Aleanizy, Fadilah Sfouq Dastageer, Mohamed A. Sci Rep Article Chemotherapy, the most commonly used therapeutic method for cancer, has the inherent constraint of low bioavailability. A number of physical cancer therapeutic treatments like radiation, ultrasound, photo-acoustic/photo thermal, microwave therapies are based on locating the afflicted sites with the help of imaging, but the serious drawbacks of these treatment options are that they damage the neighboring normal tissues and/or induce undesired cancer metastasis. In addition, these methods of treatment are very expensive and not in the reach of a common man especially in the developing countries. Therefore, innovative, less invasive and cost effective treatment methods with the help of less toxic drugs have been sought for treating cancer. In this work, photo-catalytic method of killing cancer cells, using the nanostructured silver loaded tungsten oxide (Ag/WO(3)) as photo-catalysts, in conjunction with broadband UV radiation is presented. Ag/WO(3)with two different mass ratios of Ag and WO(3) (1% Ag/WO(3) and 3% Ag/WO(3)) were synthesized, characterized and these nanostructured materials served as photo-catalysts in the process of killing cancer cells by photo-catalytic method. The advantage of loading Ag in WO(3) is quite evident from the observed increase in the photo-catalytic killing of the HeLa cells. This photo-catalytic enhancement was effectively caused by the development of Schottky junction between Ag in WO(3), which led to a substantial inhibition of photo-generated charge recombination and also by the stimulation of surface plasmon resonance in silver nanoparticles, which led to the enhanced visible light absorption by the material. Nature Publishing Group UK 2018-10-15 /pmc/articles/PMC6189059/ /pubmed/30323306 http://dx.doi.org/10.1038/s41598-018-33434-7 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article AbuMousa, Rasha A. Baig, Umair Gondal, Mohammed A. AlSalhi, Mohamad S. Alqahtani, Fulwah Yahya Akhtar, Sultan Aleanizy, Fadilah Sfouq Dastageer, Mohamed A. Photo-catalytic Killing of HeLa Cancer Cells Using Facile Synthesized Pure and Ag Loaded WO(3) Nanoparticles |
title | Photo-catalytic Killing of HeLa Cancer Cells Using Facile Synthesized Pure and Ag Loaded WO(3) Nanoparticles |
title_full | Photo-catalytic Killing of HeLa Cancer Cells Using Facile Synthesized Pure and Ag Loaded WO(3) Nanoparticles |
title_fullStr | Photo-catalytic Killing of HeLa Cancer Cells Using Facile Synthesized Pure and Ag Loaded WO(3) Nanoparticles |
title_full_unstemmed | Photo-catalytic Killing of HeLa Cancer Cells Using Facile Synthesized Pure and Ag Loaded WO(3) Nanoparticles |
title_short | Photo-catalytic Killing of HeLa Cancer Cells Using Facile Synthesized Pure and Ag Loaded WO(3) Nanoparticles |
title_sort | photo-catalytic killing of hela cancer cells using facile synthesized pure and ag loaded wo(3) nanoparticles |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189059/ https://www.ncbi.nlm.nih.gov/pubmed/30323306 http://dx.doi.org/10.1038/s41598-018-33434-7 |
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