Whole Exome Sequencing of HIV-1 long-term non-progressors identifies rare variants in genes encoding innate immune sensors and signaling molecules

Common CCR5-∆32 and HLA alleles only explain a minority of the HIV long-term non-progressor (LTNP) and elite controller (EC) phenotypes. To identify rare genetic variants contributing to the slow disease progression phenotypes, we performed whole exome sequencing (WES) on seven LTNPs and four ECs. H...

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Detalles Bibliográficos
Autores principales: Nissen, Sara Konstantin, Christiansen, Mette, Helleberg, Marie, Kjær, Kathrine, Jørgensen, Sofie Eg, Gerstoft, Jan, Katzenstein, Terese L, Benfield, Thomas, Kronborg, Gitte, Larsen, Carsten S, Laursen, Alex, Pedersen, Gitte, Jakobsen, Martin R, Tolstrup, Martin, Mogensen, Trine H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189090/
https://www.ncbi.nlm.nih.gov/pubmed/30323326
http://dx.doi.org/10.1038/s41598-018-33481-0

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