High prevalence of focal and multi-focal somatic genetic variants in the human brain

Somatic mutations during stem cell division are responsible for several cancers. In principle, a similar process could occur during the intense cell proliferation accompanying human brain development, leading to the accumulation of regionally distributed foci of mutations. Using dual platform >50...

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Detalles Bibliográficos
Autores principales: Keogh, Michael J., Wei, Wei, Aryaman, Juvid, Walker, Lauren, van den Ameele, Jelle, Coxhead, Jon, Wilson, Ian, Bashton, Matthew, Beck, Jon, West, John, Chen, Richard, Haudenschild, Christian, Bartha, Gabor, Luo, Shujun, Morris, Chris M., Jones, Nick S., Attems, Johannes, Chinnery, Patrick F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189186/
https://www.ncbi.nlm.nih.gov/pubmed/30323172
http://dx.doi.org/10.1038/s41467-018-06331-w

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