The thiosemicarbazone Me(2)NNMe(2) induces paraptosis by disrupting the ER thiol redox homeostasis based on protein disulfide isomerase inhibition

Due to their high biological activity, thiosemicarbazones have been developed for treatment of diverse diseases, including cancer, resulting in multiple clinical trials especially of the lead compound Triapine. During the last years, a novel subclass of anticancer thiosemicarbazones has attracted su...

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Detalles Bibliográficos
Autores principales: Hager, Sonja, Korbula, Katharina, Bielec, Björn, Grusch, Michael, Pirker, Christine, Schosserer, Markus, Liendl, Lisa, Lang, Magdalena, Grillari, Johannes, Nowikovsky, Karin, Pape, Veronika F. S., Mohr, Thomas, Szakács, Gergely, Keppler, Bernhard K., Berger, Walter, Kowol, Christian R., Heffeter, Petra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189190/
https://www.ncbi.nlm.nih.gov/pubmed/30323190
http://dx.doi.org/10.1038/s41419-018-1102-z

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