Targeting peroxiredoxin 1 impairs growth of breast cancer cells and potently sensitises these cells to prooxidant agents

BACKGROUND: Our previous work has shown peroxiredoxin-1 (PRDX1), one of major antioxidant enzymes, to be a biomarker in human breast cancer. Hereby, we further investigate the role of PRDX1, compared to its close homolog PRDX2, in mammary malignant cells. METHODS: CRISPR/Cas9- or RNAi-based methods...

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Detalles Bibliográficos
Autores principales: Bajor, Malgorzata, Zych, Agata O., Graczyk-Jarzynka, Agnieszka, Muchowicz, Angelika, Firczuk, Malgorzata, Trzeciak, Lech, Gaj, Pawel, Domagala, Antoni, Siernicka, Marta, Zagozdzon, Agnieszka, Siedlecki, Pawel, Kniotek, Monika, O’Leary, Patrick C., Golab, Jakub, Zagozdzon, Radoslaw
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189216/
https://www.ncbi.nlm.nih.gov/pubmed/30287919
http://dx.doi.org/10.1038/s41416-018-0263-y

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