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The MacroH2A1.1 – PARP1 Axis at the Intersection Between Stress Response and Metabolism
The exchange of replication-coupled canonical histones by histone variants endows chromatin with specific features. The replacement of the canonical H2A histone for the histone variant macroH2A is one of the most remarkable epigenetic modifications. The three vertebrate macroH2A proteins have a uniq...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189284/ https://www.ncbi.nlm.nih.gov/pubmed/30356649 http://dx.doi.org/10.3389/fgene.2018.00417 |
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author | Hurtado-Bagès, Sarah Guberovic, Iva Buschbeck, Marcus |
author_facet | Hurtado-Bagès, Sarah Guberovic, Iva Buschbeck, Marcus |
author_sort | Hurtado-Bagès, Sarah |
collection | PubMed |
description | The exchange of replication-coupled canonical histones by histone variants endows chromatin with specific features. The replacement of the canonical H2A histone for the histone variant macroH2A is one of the most remarkable epigenetic modifications. The three vertebrate macroH2A proteins have a unique tripartite structure consisting of H2A-like domain, unstructured linker, and macrodomain. Macrodomains are ancient globular folds that are able to bind nicotinamide adenine dinucleotide (NAD(+)) derived metabolites. Here, we will briefly describe the physiological relevance of the metabolite binding in the context of chromatin. In particular, we will focus on the macroH2A1.1 isoform that binds ADP-ribose and poly-ADP-ribose polymerase 1 (PARP1) enzyme, a cellular stress sensor. We will discuss the impact of this interaction in the context of cancer, senescence, cell stress and energy metabolism. |
format | Online Article Text |
id | pubmed-6189284 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-61892842018-10-23 The MacroH2A1.1 – PARP1 Axis at the Intersection Between Stress Response and Metabolism Hurtado-Bagès, Sarah Guberovic, Iva Buschbeck, Marcus Front Genet Genetics The exchange of replication-coupled canonical histones by histone variants endows chromatin with specific features. The replacement of the canonical H2A histone for the histone variant macroH2A is one of the most remarkable epigenetic modifications. The three vertebrate macroH2A proteins have a unique tripartite structure consisting of H2A-like domain, unstructured linker, and macrodomain. Macrodomains are ancient globular folds that are able to bind nicotinamide adenine dinucleotide (NAD(+)) derived metabolites. Here, we will briefly describe the physiological relevance of the metabolite binding in the context of chromatin. In particular, we will focus on the macroH2A1.1 isoform that binds ADP-ribose and poly-ADP-ribose polymerase 1 (PARP1) enzyme, a cellular stress sensor. We will discuss the impact of this interaction in the context of cancer, senescence, cell stress and energy metabolism. Frontiers Media S.A. 2018-10-09 /pmc/articles/PMC6189284/ /pubmed/30356649 http://dx.doi.org/10.3389/fgene.2018.00417 Text en Copyright © 2018 Hurtado-Bagès, Guberovic and Buschbeck. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Genetics Hurtado-Bagès, Sarah Guberovic, Iva Buschbeck, Marcus The MacroH2A1.1 – PARP1 Axis at the Intersection Between Stress Response and Metabolism |
title | The MacroH2A1.1 – PARP1 Axis at the Intersection Between Stress Response and Metabolism |
title_full | The MacroH2A1.1 – PARP1 Axis at the Intersection Between Stress Response and Metabolism |
title_fullStr | The MacroH2A1.1 – PARP1 Axis at the Intersection Between Stress Response and Metabolism |
title_full_unstemmed | The MacroH2A1.1 – PARP1 Axis at the Intersection Between Stress Response and Metabolism |
title_short | The MacroH2A1.1 – PARP1 Axis at the Intersection Between Stress Response and Metabolism |
title_sort | macroh2a1.1 – parp1 axis at the intersection between stress response and metabolism |
topic | Genetics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189284/ https://www.ncbi.nlm.nih.gov/pubmed/30356649 http://dx.doi.org/10.3389/fgene.2018.00417 |
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