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A Model for Trans-Kingdom Pathogenicity in Fonsecaea Agents of Human Chromoblastomycosis
The fungal genus Fonsecaea comprises etiological agents of human chromoblastomycosis, a chronic implantation skin disease. The current hypothesis is that patients acquire the infection through an injury from plant material. The present study aimed to evaluate a model of infection in plant and animal...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189323/ https://www.ncbi.nlm.nih.gov/pubmed/30356683 http://dx.doi.org/10.3389/fmicb.2018.02211 |
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| author | Fornari, Gheniffer Gomes, Renata Rodrigues Degenhardt-Goldbach, Juliana dos Santos, Suelen Silvana de Almeida, Sandro Rogério dos Santos, Germana Davila Muro, Marisol Dominguez Bona, Cleusa Scola, Rosana Herminia Trindade, Edvaldo S. Bini, Israel Henrique Ferreira-Maba, Lisandra Santos Kestring, Daiane Rigoni do Nascimento, Mariana Machado Fidelis Lima, Bruna Jacomel Favoreto de Souza Voidaleski, Morgana F. Steinmacher, Douglas André Soley, Bruna da Silva Deng, Shuwen Bocca, Anamelia Lorenzetti da Silva, Moises B. Salgado, Claudio G. de Azevedo, Conceição Maria Pedroso e Silva Vicente, Vania Aparecida de Hoog, Sybren |
| author_facet | Fornari, Gheniffer Gomes, Renata Rodrigues Degenhardt-Goldbach, Juliana dos Santos, Suelen Silvana de Almeida, Sandro Rogério dos Santos, Germana Davila Muro, Marisol Dominguez Bona, Cleusa Scola, Rosana Herminia Trindade, Edvaldo S. Bini, Israel Henrique Ferreira-Maba, Lisandra Santos Kestring, Daiane Rigoni do Nascimento, Mariana Machado Fidelis Lima, Bruna Jacomel Favoreto de Souza Voidaleski, Morgana F. Steinmacher, Douglas André Soley, Bruna da Silva Deng, Shuwen Bocca, Anamelia Lorenzetti da Silva, Moises B. Salgado, Claudio G. de Azevedo, Conceição Maria Pedroso e Silva Vicente, Vania Aparecida de Hoog, Sybren |
| author_sort | Fornari, Gheniffer |
| collection | PubMed |
| description | The fungal genus Fonsecaea comprises etiological agents of human chromoblastomycosis, a chronic implantation skin disease. The current hypothesis is that patients acquire the infection through an injury from plant material. The present study aimed to evaluate a model of infection in plant and animal hosts to understand the parameters of trans-kingdom pathogenicity. Clinical strains of causative agents of chromoblastomycosis (Fonsecaea pedrosoi and Fonsecaea monophora) were compared with a strain of Fonsecaea erecta isolated from a living plant. The clinical strains of F. monophora and F. pedrosoi remained concentrated near the epidermis, whereas F. erecta colonized deeper plant tissues, resembling an endophytic behavior. In an invertebrate infection model with larvae of a beetle, Tenebrio molitor, F. erecta exhibited the lowest survival rates. However, F. pedrosoi produced dark, spherical to ovoidal cells that resembled muriform cells, the invasive form of human chromoblastomycosis confirming the role of muriform cells as a pathogenic adaptation in animal tissues. An immunologic assay in BALB/c mice demonstrated the high virulence of saprobic species in animal models was subsequently controlled via host higher immune response. |
| format | Online Article Text |
| id | pubmed-6189323 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2018 |
| publisher | Frontiers Media S.A. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-61893232018-10-23 A Model for Trans-Kingdom Pathogenicity in Fonsecaea Agents of Human Chromoblastomycosis Fornari, Gheniffer Gomes, Renata Rodrigues Degenhardt-Goldbach, Juliana dos Santos, Suelen Silvana de Almeida, Sandro Rogério dos Santos, Germana Davila Muro, Marisol Dominguez Bona, Cleusa Scola, Rosana Herminia Trindade, Edvaldo S. Bini, Israel Henrique Ferreira-Maba, Lisandra Santos Kestring, Daiane Rigoni do Nascimento, Mariana Machado Fidelis Lima, Bruna Jacomel Favoreto de Souza Voidaleski, Morgana F. Steinmacher, Douglas André Soley, Bruna da Silva Deng, Shuwen Bocca, Anamelia Lorenzetti da Silva, Moises B. Salgado, Claudio G. de Azevedo, Conceição Maria Pedroso e Silva Vicente, Vania Aparecida de Hoog, Sybren Front Microbiol Microbiology The fungal genus Fonsecaea comprises etiological agents of human chromoblastomycosis, a chronic implantation skin disease. The current hypothesis is that patients acquire the infection through an injury from plant material. The present study aimed to evaluate a model of infection in plant and animal hosts to understand the parameters of trans-kingdom pathogenicity. Clinical strains of causative agents of chromoblastomycosis (Fonsecaea pedrosoi and Fonsecaea monophora) were compared with a strain of Fonsecaea erecta isolated from a living plant. The clinical strains of F. monophora and F. pedrosoi remained concentrated near the epidermis, whereas F. erecta colonized deeper plant tissues, resembling an endophytic behavior. In an invertebrate infection model with larvae of a beetle, Tenebrio molitor, F. erecta exhibited the lowest survival rates. However, F. pedrosoi produced dark, spherical to ovoidal cells that resembled muriform cells, the invasive form of human chromoblastomycosis confirming the role of muriform cells as a pathogenic adaptation in animal tissues. An immunologic assay in BALB/c mice demonstrated the high virulence of saprobic species in animal models was subsequently controlled via host higher immune response. Frontiers Media S.A. 2018-10-09 /pmc/articles/PMC6189323/ /pubmed/30356683 http://dx.doi.org/10.3389/fmicb.2018.02211 Text en Copyright © 2018 Fornari, Gomes, Degenhardt-Goldbach, Santos, Almeida, Santos, Muro, Bona, Trindade, Bini, Ferreira-Maba, Soley, Kestring, Nascimento, Lima, Voidaleski, Steinmacher, Scola, Deng, Bocca, da Silva, Salgado, de Azevedo, Vicente and de Hoog. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| spellingShingle | Microbiology Fornari, Gheniffer Gomes, Renata Rodrigues Degenhardt-Goldbach, Juliana dos Santos, Suelen Silvana de Almeida, Sandro Rogério dos Santos, Germana Davila Muro, Marisol Dominguez Bona, Cleusa Scola, Rosana Herminia Trindade, Edvaldo S. Bini, Israel Henrique Ferreira-Maba, Lisandra Santos Kestring, Daiane Rigoni do Nascimento, Mariana Machado Fidelis Lima, Bruna Jacomel Favoreto de Souza Voidaleski, Morgana F. Steinmacher, Douglas André Soley, Bruna da Silva Deng, Shuwen Bocca, Anamelia Lorenzetti da Silva, Moises B. Salgado, Claudio G. de Azevedo, Conceição Maria Pedroso e Silva Vicente, Vania Aparecida de Hoog, Sybren A Model for Trans-Kingdom Pathogenicity in Fonsecaea Agents of Human Chromoblastomycosis |
| title | A Model for Trans-Kingdom Pathogenicity in Fonsecaea Agents of Human Chromoblastomycosis |
| title_full | A Model for Trans-Kingdom Pathogenicity in Fonsecaea Agents of Human Chromoblastomycosis |
| title_fullStr | A Model for Trans-Kingdom Pathogenicity in Fonsecaea Agents of Human Chromoblastomycosis |
| title_full_unstemmed | A Model for Trans-Kingdom Pathogenicity in Fonsecaea Agents of Human Chromoblastomycosis |
| title_short | A Model for Trans-Kingdom Pathogenicity in Fonsecaea Agents of Human Chromoblastomycosis |
| title_sort | model for trans-kingdom pathogenicity in fonsecaea agents of human chromoblastomycosis |
| topic | Microbiology |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189323/ https://www.ncbi.nlm.nih.gov/pubmed/30356683 http://dx.doi.org/10.3389/fmicb.2018.02211 |
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