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Population pharmacokinetics of extended‐release levetiracetam in epileptic dogs when administered alone, with phenobarbital or zonisamide

BACKGROUND: Extended‐release levetiracetam (LEV‐XR) has gained acceptance as an antiepileptic drug in dogs. No studies have evaluated its disposition in dogs with epilepsy. HYPOTHESIS/OBJECTIVES: To evaluate the pharmacokinetics of LEV‐XR in epileptic dogs when administered alone or with phenobarbit...

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Detalles Bibliográficos
Autores principales: Muñana, Karen R., Otamendi, Arturo J., Nettifee, Julie A., Papich, Mark G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189379/
https://www.ncbi.nlm.nih.gov/pubmed/30238679
http://dx.doi.org/10.1111/jvim.15298