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Dual Activation of Phosphodiesterases 3 and 4 Regulates Basal Spontaneous Beating Rate of Cardiac Pacemaker Cells: Role of Compartmentalization?

Spontaneous firing of sinoatrial (SA) node cells (SANCs) is regulated by cyclic adenosine monophosphate (cAMP)-mediated, protein kinase A (PKA)-dependent (cAMP/PKA) local subsarcolemmal Ca(2+) releases (LCRs) from ryanodine receptors (RyR). The LCRs occur during diastolic depolarization (DD) and act...

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Detalles Bibliográficos
Autores principales:	Vinogradova, Tatiana M., Kobrinsky, Evgeny, Lakatta, Edward G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Physiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189467/ https://www.ncbi.nlm.nih.gov/pubmed/30356755 http://dx.doi.org/10.3389/fphys.2018.01301

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