Microfluidic Autologous Serum Eye-Drops Preparation as a Potential Dry Eye Treatment

Dry eye is a problem in tearing quality and/or quantity and it afflicts millions of persons worldwide. An autologous serum eye-drop is a good candidate for dry eye treatment; however, the eye-drop preparation procedures take a long time and are relatively troublesome. Here we use spiral microchannel...

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Autores principales: Yasui, Takao, Morikawa, Jumpei, Kaji, Noritada, Tokeshi, Manabu, Tsubota, Kazuo, Baba, Yoshinobu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189724/
https://www.ncbi.nlm.nih.gov/pubmed/30404287
http://dx.doi.org/10.3390/mi7070113
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author Yasui, Takao
Morikawa, Jumpei
Kaji, Noritada
Tokeshi, Manabu
Tsubota, Kazuo
Baba, Yoshinobu
author_facet Yasui, Takao
Morikawa, Jumpei
Kaji, Noritada
Tokeshi, Manabu
Tsubota, Kazuo
Baba, Yoshinobu
author_sort Yasui, Takao
collection PubMed
description Dry eye is a problem in tearing quality and/or quantity and it afflicts millions of persons worldwide. An autologous serum eye-drop is a good candidate for dry eye treatment; however, the eye-drop preparation procedures take a long time and are relatively troublesome. Here we use spiral microchannels to demonstrate a strategy for the preparation of autologous serum eye-drops, which provide benefits for all dry eye patients; 100% and 90% removal efficiencies are achieved for 10 μm microbeads and whole human blood cells, respectively. Since our strategy allows researchers to integrate other functional microchannels into one device, such a microfluidic device will be able to offer a new one-step preparation system for autologous serum eye-drops.
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spelling pubmed-61897242018-11-01 Microfluidic Autologous Serum Eye-Drops Preparation as a Potential Dry Eye Treatment Yasui, Takao Morikawa, Jumpei Kaji, Noritada Tokeshi, Manabu Tsubota, Kazuo Baba, Yoshinobu Micromachines (Basel) Communication Dry eye is a problem in tearing quality and/or quantity and it afflicts millions of persons worldwide. An autologous serum eye-drop is a good candidate for dry eye treatment; however, the eye-drop preparation procedures take a long time and are relatively troublesome. Here we use spiral microchannels to demonstrate a strategy for the preparation of autologous serum eye-drops, which provide benefits for all dry eye patients; 100% and 90% removal efficiencies are achieved for 10 μm microbeads and whole human blood cells, respectively. Since our strategy allows researchers to integrate other functional microchannels into one device, such a microfluidic device will be able to offer a new one-step preparation system for autologous serum eye-drops. MDPI 2016-07-04 /pmc/articles/PMC6189724/ /pubmed/30404287 http://dx.doi.org/10.3390/mi7070113 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Yasui, Takao
Morikawa, Jumpei
Kaji, Noritada
Tokeshi, Manabu
Tsubota, Kazuo
Baba, Yoshinobu
Microfluidic Autologous Serum Eye-Drops Preparation as a Potential Dry Eye Treatment
title Microfluidic Autologous Serum Eye-Drops Preparation as a Potential Dry Eye Treatment
title_full Microfluidic Autologous Serum Eye-Drops Preparation as a Potential Dry Eye Treatment
title_fullStr Microfluidic Autologous Serum Eye-Drops Preparation as a Potential Dry Eye Treatment
title_full_unstemmed Microfluidic Autologous Serum Eye-Drops Preparation as a Potential Dry Eye Treatment
title_short Microfluidic Autologous Serum Eye-Drops Preparation as a Potential Dry Eye Treatment
title_sort microfluidic autologous serum eye-drops preparation as a potential dry eye treatment
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189724/
https://www.ncbi.nlm.nih.gov/pubmed/30404287
http://dx.doi.org/10.3390/mi7070113
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