Cargando…
Photochemical Synthesis and Versatile Functionalization Method of a Robust Porous Poly(ethylene glycol methacrylate-co-allyl methacrylate) Monolith Dedicated to Radiochemical Separation in a Centrifugal Microfluidic Platform
The use of a centrifugal microfluidic platform is an alternative to classical chromatographic procedures for radiochemistry. An ion-exchange support with respect to the in situ light-addressable process of elaboration is specifically designed to be incorporated as a radiochemical sample preparation...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189732/ https://www.ncbi.nlm.nih.gov/pubmed/30407417 http://dx.doi.org/10.3390/mi7030045 |
_version_ | 1783363420595159040 |
---|---|
author | Losno, Marion Ferrante, Ivan Brennetot, René Varlet, Jérôme Blanc, Cécile Grenut, Bernard Amblard, Etienne Descroix, Stéphanie Mariet, Clarisse |
author_facet | Losno, Marion Ferrante, Ivan Brennetot, René Varlet, Jérôme Blanc, Cécile Grenut, Bernard Amblard, Etienne Descroix, Stéphanie Mariet, Clarisse |
author_sort | Losno, Marion |
collection | PubMed |
description | The use of a centrifugal microfluidic platform is an alternative to classical chromatographic procedures for radiochemistry. An ion-exchange support with respect to the in situ light-addressable process of elaboration is specifically designed to be incorporated as a radiochemical sample preparation module in centrifugal microsystem devices. This paper presents a systematic study of the synthesis of the polymeric porous monolith poly(ethylene glycol methacrylate-co-allyl methacrylate) used as a solid-phase support and the versatile and robust photografting process of the monolith based on thiol-ene click chemistry. The polymerization reaction is investigated, varying the formulation of the polymerisable mixture. The robustness of the stationary phase was tested in concentrated nitric acid. Thanks to their unique “easy-to-use” features, centrifugal microfluidic platforms are potential successful candidates for the downscaling of chromatographic separation of radioactive samples (automation, multiplexing, easy integration in glove-boxes environment, and low cost of maintenance). |
format | Online Article Text |
id | pubmed-6189732 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-61897322018-11-01 Photochemical Synthesis and Versatile Functionalization Method of a Robust Porous Poly(ethylene glycol methacrylate-co-allyl methacrylate) Monolith Dedicated to Radiochemical Separation in a Centrifugal Microfluidic Platform Losno, Marion Ferrante, Ivan Brennetot, René Varlet, Jérôme Blanc, Cécile Grenut, Bernard Amblard, Etienne Descroix, Stéphanie Mariet, Clarisse Micromachines (Basel) Article The use of a centrifugal microfluidic platform is an alternative to classical chromatographic procedures for radiochemistry. An ion-exchange support with respect to the in situ light-addressable process of elaboration is specifically designed to be incorporated as a radiochemical sample preparation module in centrifugal microsystem devices. This paper presents a systematic study of the synthesis of the polymeric porous monolith poly(ethylene glycol methacrylate-co-allyl methacrylate) used as a solid-phase support and the versatile and robust photografting process of the monolith based on thiol-ene click chemistry. The polymerization reaction is investigated, varying the formulation of the polymerisable mixture. The robustness of the stationary phase was tested in concentrated nitric acid. Thanks to their unique “easy-to-use” features, centrifugal microfluidic platforms are potential successful candidates for the downscaling of chromatographic separation of radioactive samples (automation, multiplexing, easy integration in glove-boxes environment, and low cost of maintenance). MDPI 2016-03-10 /pmc/articles/PMC6189732/ /pubmed/30407417 http://dx.doi.org/10.3390/mi7030045 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Losno, Marion Ferrante, Ivan Brennetot, René Varlet, Jérôme Blanc, Cécile Grenut, Bernard Amblard, Etienne Descroix, Stéphanie Mariet, Clarisse Photochemical Synthesis and Versatile Functionalization Method of a Robust Porous Poly(ethylene glycol methacrylate-co-allyl methacrylate) Monolith Dedicated to Radiochemical Separation in a Centrifugal Microfluidic Platform |
title | Photochemical Synthesis and Versatile Functionalization Method of a Robust Porous Poly(ethylene glycol methacrylate-co-allyl methacrylate) Monolith Dedicated to Radiochemical Separation in a Centrifugal Microfluidic Platform |
title_full | Photochemical Synthesis and Versatile Functionalization Method of a Robust Porous Poly(ethylene glycol methacrylate-co-allyl methacrylate) Monolith Dedicated to Radiochemical Separation in a Centrifugal Microfluidic Platform |
title_fullStr | Photochemical Synthesis and Versatile Functionalization Method of a Robust Porous Poly(ethylene glycol methacrylate-co-allyl methacrylate) Monolith Dedicated to Radiochemical Separation in a Centrifugal Microfluidic Platform |
title_full_unstemmed | Photochemical Synthesis and Versatile Functionalization Method of a Robust Porous Poly(ethylene glycol methacrylate-co-allyl methacrylate) Monolith Dedicated to Radiochemical Separation in a Centrifugal Microfluidic Platform |
title_short | Photochemical Synthesis and Versatile Functionalization Method of a Robust Porous Poly(ethylene glycol methacrylate-co-allyl methacrylate) Monolith Dedicated to Radiochemical Separation in a Centrifugal Microfluidic Platform |
title_sort | photochemical synthesis and versatile functionalization method of a robust porous poly(ethylene glycol methacrylate-co-allyl methacrylate) monolith dedicated to radiochemical separation in a centrifugal microfluidic platform |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189732/ https://www.ncbi.nlm.nih.gov/pubmed/30407417 http://dx.doi.org/10.3390/mi7030045 |
work_keys_str_mv | AT losnomarion photochemicalsynthesisandversatilefunctionalizationmethodofarobustporouspolyethyleneglycolmethacrylatecoallylmethacrylatemonolithdedicatedtoradiochemicalseparationinacentrifugalmicrofluidicplatform AT ferranteivan photochemicalsynthesisandversatilefunctionalizationmethodofarobustporouspolyethyleneglycolmethacrylatecoallylmethacrylatemonolithdedicatedtoradiochemicalseparationinacentrifugalmicrofluidicplatform AT brennetotrene photochemicalsynthesisandversatilefunctionalizationmethodofarobustporouspolyethyleneglycolmethacrylatecoallylmethacrylatemonolithdedicatedtoradiochemicalseparationinacentrifugalmicrofluidicplatform AT varletjerome photochemicalsynthesisandversatilefunctionalizationmethodofarobustporouspolyethyleneglycolmethacrylatecoallylmethacrylatemonolithdedicatedtoradiochemicalseparationinacentrifugalmicrofluidicplatform AT blanccecile photochemicalsynthesisandversatilefunctionalizationmethodofarobustporouspolyethyleneglycolmethacrylatecoallylmethacrylatemonolithdedicatedtoradiochemicalseparationinacentrifugalmicrofluidicplatform AT grenutbernard photochemicalsynthesisandversatilefunctionalizationmethodofarobustporouspolyethyleneglycolmethacrylatecoallylmethacrylatemonolithdedicatedtoradiochemicalseparationinacentrifugalmicrofluidicplatform AT amblardetienne photochemicalsynthesisandversatilefunctionalizationmethodofarobustporouspolyethyleneglycolmethacrylatecoallylmethacrylatemonolithdedicatedtoradiochemicalseparationinacentrifugalmicrofluidicplatform AT descroixstephanie photochemicalsynthesisandversatilefunctionalizationmethodofarobustporouspolyethyleneglycolmethacrylatecoallylmethacrylatemonolithdedicatedtoradiochemicalseparationinacentrifugalmicrofluidicplatform AT marietclarisse photochemicalsynthesisandversatilefunctionalizationmethodofarobustporouspolyethyleneglycolmethacrylatecoallylmethacrylatemonolithdedicatedtoradiochemicalseparationinacentrifugalmicrofluidicplatform |