Cargando…

Paper-Based Microfluidic Device with a Gold Nanosensor to Detect Arsenic Contamination of Groundwater in Bangladesh

In this paper, we present a microfluidic paper-based analytical device (μPAD) with a gold nanosensor functionalized with α-lipoic acid and thioguanine (Au–TA–TG) to detect whether the arsenic level of groundwater from hand tubewells in Bangladesh is above or below the World Health Organization (WHO)...

Descripción completa

Detalles Bibliográficos
Autores principales: Chowdury, Mosfera A., Walji, Noosheen, Mahmud, Md. Almostasim, MacDonald, Brendan D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189735/
http://dx.doi.org/10.3390/mi8030071
_version_ 1783363421274636288
author Chowdury, Mosfera A.
Walji, Noosheen
Mahmud, Md. Almostasim
MacDonald, Brendan D.
author_facet Chowdury, Mosfera A.
Walji, Noosheen
Mahmud, Md. Almostasim
MacDonald, Brendan D.
author_sort Chowdury, Mosfera A.
collection PubMed
description In this paper, we present a microfluidic paper-based analytical device (μPAD) with a gold nanosensor functionalized with α-lipoic acid and thioguanine (Au–TA–TG) to detect whether the arsenic level of groundwater from hand tubewells in Bangladesh is above or below the World Health Organization (WHO) guideline level of 10 μg/L. We analyzed the naturally occurring metals present in Bangladesh groundwater and assessed the interference with the gold nanosensor. A method was developed to prevent interference from alkaline metals found in Bangladesh groundwater (Ca, Mg, K and Na) by increasing the pH level on the μPADs to 12.1. Most of the heavy metals present in the groundwater (Ni, Mn, Cd, Pb, and Fe II) did not interfere with the μPAD arsenic tests; however, Fe III was found to interfere, which was also prevented by increasing the pH level on the μPADs to 12.1. The μPAD arsenic tests were tested with 24 groundwater samples collected from hand tubewells in three different districts in Bangladesh: Shirajganj, Manikganj, and Munshiganj, and the predictions for whether the arsenic levels were above or below the WHO guideline level agreed with the results obtained from laboratory testing. The μPAD arsenic test is the first paper-based test validated using Bangladesh groundwater samples and capable of detecting whether the arsenic level in groundwater is above or below the WHO guideline level of 10 μg/L, which is a step towards enabling the villagers who collect and consume the groundwater to test their own sources and make decisions about where to obtain the safest water.
format Online
Article
Text
id pubmed-6189735
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-61897352018-11-01 Paper-Based Microfluidic Device with a Gold Nanosensor to Detect Arsenic Contamination of Groundwater in Bangladesh Chowdury, Mosfera A. Walji, Noosheen Mahmud, Md. Almostasim MacDonald, Brendan D. Micromachines (Basel) Article In this paper, we present a microfluidic paper-based analytical device (μPAD) with a gold nanosensor functionalized with α-lipoic acid and thioguanine (Au–TA–TG) to detect whether the arsenic level of groundwater from hand tubewells in Bangladesh is above or below the World Health Organization (WHO) guideline level of 10 μg/L. We analyzed the naturally occurring metals present in Bangladesh groundwater and assessed the interference with the gold nanosensor. A method was developed to prevent interference from alkaline metals found in Bangladesh groundwater (Ca, Mg, K and Na) by increasing the pH level on the μPADs to 12.1. Most of the heavy metals present in the groundwater (Ni, Mn, Cd, Pb, and Fe II) did not interfere with the μPAD arsenic tests; however, Fe III was found to interfere, which was also prevented by increasing the pH level on the μPADs to 12.1. The μPAD arsenic tests were tested with 24 groundwater samples collected from hand tubewells in three different districts in Bangladesh: Shirajganj, Manikganj, and Munshiganj, and the predictions for whether the arsenic levels were above or below the WHO guideline level agreed with the results obtained from laboratory testing. The μPAD arsenic test is the first paper-based test validated using Bangladesh groundwater samples and capable of detecting whether the arsenic level in groundwater is above or below the WHO guideline level of 10 μg/L, which is a step towards enabling the villagers who collect and consume the groundwater to test their own sources and make decisions about where to obtain the safest water. MDPI 2017-03-01 /pmc/articles/PMC6189735/ http://dx.doi.org/10.3390/mi8030071 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chowdury, Mosfera A.
Walji, Noosheen
Mahmud, Md. Almostasim
MacDonald, Brendan D.
Paper-Based Microfluidic Device with a Gold Nanosensor to Detect Arsenic Contamination of Groundwater in Bangladesh
title Paper-Based Microfluidic Device with a Gold Nanosensor to Detect Arsenic Contamination of Groundwater in Bangladesh
title_full Paper-Based Microfluidic Device with a Gold Nanosensor to Detect Arsenic Contamination of Groundwater in Bangladesh
title_fullStr Paper-Based Microfluidic Device with a Gold Nanosensor to Detect Arsenic Contamination of Groundwater in Bangladesh
title_full_unstemmed Paper-Based Microfluidic Device with a Gold Nanosensor to Detect Arsenic Contamination of Groundwater in Bangladesh
title_short Paper-Based Microfluidic Device with a Gold Nanosensor to Detect Arsenic Contamination of Groundwater in Bangladesh
title_sort paper-based microfluidic device with a gold nanosensor to detect arsenic contamination of groundwater in bangladesh
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189735/
http://dx.doi.org/10.3390/mi8030071
work_keys_str_mv AT chowdurymosferaa paperbasedmicrofluidicdevicewithagoldnanosensortodetectarseniccontaminationofgroundwaterinbangladesh
AT waljinoosheen paperbasedmicrofluidicdevicewithagoldnanosensortodetectarseniccontaminationofgroundwaterinbangladesh
AT mahmudmdalmostasim paperbasedmicrofluidicdevicewithagoldnanosensortodetectarseniccontaminationofgroundwaterinbangladesh
AT macdonaldbrendand paperbasedmicrofluidicdevicewithagoldnanosensortodetectarseniccontaminationofgroundwaterinbangladesh