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Simulation, Fabrication and Analysis of Silver Based Ascending Sinusoidal Microchannel (ASMC) for Implant of Varicose Veins

Bioengineered veins can benefit humans needing bypass surgery, dialysis, and now, in the treatment of varicose veins. The implant of this vein in varicose veins has significant advantages over the conventional treatment methods. Deep vein thrombosis (DVT), vein patch repair, pulmonary embolus, and t...

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Autores principales: Afzal, Muhammad Javaid, Tayyaba, Shahzadi, Ashraf, Muhammad Waseem, Hossain, M. Khalid, Uddin, M. Jalal, Afzulpurkar, Nitin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189736/
https://www.ncbi.nlm.nih.gov/pubmed/30400469
http://dx.doi.org/10.3390/mi8090278
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author Afzal, Muhammad Javaid
Tayyaba, Shahzadi
Ashraf, Muhammad Waseem
Hossain, M. Khalid
Uddin, M. Jalal
Afzulpurkar, Nitin
author_facet Afzal, Muhammad Javaid
Tayyaba, Shahzadi
Ashraf, Muhammad Waseem
Hossain, M. Khalid
Uddin, M. Jalal
Afzulpurkar, Nitin
author_sort Afzal, Muhammad Javaid
collection PubMed
description Bioengineered veins can benefit humans needing bypass surgery, dialysis, and now, in the treatment of varicose veins. The implant of this vein in varicose veins has significant advantages over the conventional treatment methods. Deep vein thrombosis (DVT), vein patch repair, pulmonary embolus, and tissue-damaging problems can be solved with this implant. Here, the authors have proposed biomedical microdevices as an alternative for varicose veins. MATLAB and ANSYS Fluent have been used for simulations of blood flow for bioengineered veins. The silver based microchannel has been fabricated by using a micromachining process. The dimensions of the silver substrates are 51 mm, 25 mm, and 1.1 mm, in length, width, and depth respectively. The dimensions of microchannels grooved in the substrates are 0.9 mm in width and depth. The boundary conditions for pressure and velocity were considered, from 1.0 kPa to 1.50 kPa, and 0.02 m/s to 0.07 m/s, respectively. These are the actual values of pressure and velocity in varicose veins. The flow rate of 5.843 (0.1 nL/s) and velocity of 5.843 cm/s were determined at Reynolds number 164.88 in experimental testing. The graphs and results from simulations and experiments are in close agreement. These microchannels can be inserted into varicose veins as a replacement to maintain the excellent blood flow in human legs.
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spelling pubmed-61897362018-11-01 Simulation, Fabrication and Analysis of Silver Based Ascending Sinusoidal Microchannel (ASMC) for Implant of Varicose Veins Afzal, Muhammad Javaid Tayyaba, Shahzadi Ashraf, Muhammad Waseem Hossain, M. Khalid Uddin, M. Jalal Afzulpurkar, Nitin Micromachines (Basel) Article Bioengineered veins can benefit humans needing bypass surgery, dialysis, and now, in the treatment of varicose veins. The implant of this vein in varicose veins has significant advantages over the conventional treatment methods. Deep vein thrombosis (DVT), vein patch repair, pulmonary embolus, and tissue-damaging problems can be solved with this implant. Here, the authors have proposed biomedical microdevices as an alternative for varicose veins. MATLAB and ANSYS Fluent have been used for simulations of blood flow for bioengineered veins. The silver based microchannel has been fabricated by using a micromachining process. The dimensions of the silver substrates are 51 mm, 25 mm, and 1.1 mm, in length, width, and depth respectively. The dimensions of microchannels grooved in the substrates are 0.9 mm in width and depth. The boundary conditions for pressure and velocity were considered, from 1.0 kPa to 1.50 kPa, and 0.02 m/s to 0.07 m/s, respectively. These are the actual values of pressure and velocity in varicose veins. The flow rate of 5.843 (0.1 nL/s) and velocity of 5.843 cm/s were determined at Reynolds number 164.88 in experimental testing. The graphs and results from simulations and experiments are in close agreement. These microchannels can be inserted into varicose veins as a replacement to maintain the excellent blood flow in human legs. MDPI 2017-09-14 /pmc/articles/PMC6189736/ /pubmed/30400469 http://dx.doi.org/10.3390/mi8090278 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Afzal, Muhammad Javaid
Tayyaba, Shahzadi
Ashraf, Muhammad Waseem
Hossain, M. Khalid
Uddin, M. Jalal
Afzulpurkar, Nitin
Simulation, Fabrication and Analysis of Silver Based Ascending Sinusoidal Microchannel (ASMC) for Implant of Varicose Veins
title Simulation, Fabrication and Analysis of Silver Based Ascending Sinusoidal Microchannel (ASMC) for Implant of Varicose Veins
title_full Simulation, Fabrication and Analysis of Silver Based Ascending Sinusoidal Microchannel (ASMC) for Implant of Varicose Veins
title_fullStr Simulation, Fabrication and Analysis of Silver Based Ascending Sinusoidal Microchannel (ASMC) for Implant of Varicose Veins
title_full_unstemmed Simulation, Fabrication and Analysis of Silver Based Ascending Sinusoidal Microchannel (ASMC) for Implant of Varicose Veins
title_short Simulation, Fabrication and Analysis of Silver Based Ascending Sinusoidal Microchannel (ASMC) for Implant of Varicose Veins
title_sort simulation, fabrication and analysis of silver based ascending sinusoidal microchannel (asmc) for implant of varicose veins
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189736/
https://www.ncbi.nlm.nih.gov/pubmed/30400469
http://dx.doi.org/10.3390/mi8090278
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