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Analysis of the nitric oxide-cyclic guanosine monophosphate pathway in experimental liver cirrhosis suggests phosphodiesterase-5 as potential target to treat portal hypertension

AIM: To investigate the potential effect of inhibitors of phosphodiesterase-5 (PDE-5) for therapy of portal hypertension in liver cirrhosis. METHODS: In the rat model of thioacetamide-induced liver fibrosis/cirrhosis the nitric oxide-cyclic guanosine monophosphate (NO-cGMP) pathway was investigated....

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Detalles Bibliográficos
Autores principales:	Schaffner, Denise, Lazaro, Adhara, Deibert, Peter, Hasselblatt, Peter, Stoll, Patrick, Fauth, Lisa, Baumstark, Manfred W, Merfort, Irmgard, Schmitt-Graeff, Annette, Kreisel, Wolfgang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Baishideng Publishing Group Inc 2018
Materias:	Basic Study
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189851/ https://www.ncbi.nlm.nih.gov/pubmed/30344420 http://dx.doi.org/10.3748/wjg.v24.i38.4356

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