Cargando…

Analysis of the nitric oxide-cyclic guanosine monophosphate pathway in experimental liver cirrhosis suggests phosphodiesterase-5 as potential target to treat portal hypertension

AIM: To investigate the potential effect of inhibitors of phosphodiesterase-5 (PDE-5) for therapy of portal hypertension in liver cirrhosis. METHODS: In the rat model of thioacetamide-induced liver fibrosis/cirrhosis the nitric oxide-cyclic guanosine monophosphate (NO-cGMP) pathway was investigated....

Descripción completa

Detalles Bibliográficos
Autores principales:	Schaffner, Denise, Lazaro, Adhara, Deibert, Peter, Hasselblatt, Peter, Stoll, Patrick, Fauth, Lisa, Baumstark, Manfred W, Merfort, Irmgard, Schmitt-Graeff, Annette, Kreisel, Wolfgang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Baishideng Publishing Group Inc 2018
Materias:	Basic Study
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189851/ https://www.ncbi.nlm.nih.gov/pubmed/30344420 http://dx.doi.org/10.3748/wjg.v24.i38.4356

Ejemplares similares

Phosphodiesterases in the Liver as Potential Therapeutic Targets of Cirrhotic Portal Hypertension
por: Kreisel, Wolfgang, et al.
Publicado: (2020)

Cyclic GMP in Liver Cirrhosis—Role in Pathophysiology of Portal Hypertension and Therapeutic Implications
por: Kreisel, Wolfgang, et al.
Publicado: (2021)

Beneficial long term effect of a phosphodiesterase-5-inhibitor in cirrhotic portal hypertension: A case report with 8 years follow-up
por: Deibert, Peter, et al.
Publicado: (2018)

Plasma Cyclic Guanosine Monophosphate Is a Promising Biomarker of Clinically Significant Portal Hypertension in Patients With Liver Cirrhosis
por: Sturm, Lukas, et al.
Publicado: (2022)

Optogenetic manipulation of cyclic guanosine monophosphate to probe phosphodiesterase activities in megakaryocytes
por: Zhang, Yujing, et al.
Publicado: (2022)

Close Relationship between Systemic Arterial and Portal Venous Pressure in an Animal Model with Healthy Liver
por: Lazaro, Adhara, et al.
Publicado: (2023)

Monovalent selectivity of the cyclic guanosine monophosphate-activated ion channel
Publicado: (1990)

Regulation of Biofilm Exopolysaccharide Production by Cyclic Di-Guanosine Monophosphate
por: Poulin, Myles B., et al.
Publicado: (2021)

Comprehensive lifestyle intervention vs soy protein-based meal regimen in non-alcoholic steatohepatitis
por: Deibert, Peter, et al.
Publicado: (2019)

Dual Specificity and Novel Structural Folding of Yeast Phosphodiesterase-1 for Hydrolysis of Second Messengers Cyclic Adenosine and Guanosine 3′,5′-Monophosphate
por: Tian, Yuanyuan, et al.
Publicado: (2014)

Increased Adhesion and Aggregation of Platelets Lacking Cyclic Guanosine 3′,5′-Monophosphate Kinase I
por: Massberg, Steffen, et al.
Publicado: (1999)

Guanosine 3',5'-cyclic monophosphate and the in vitro physiology of frog photoreceptor membranes
Publicado: (1977)

Associations Between the Cyclic Guanosine Monophosphate Pathway and Cardiovascular Risk Factors: MESA
por: Ying, Wendy, et al.
Publicado: (2019)

Cyclic Guanosine Monophosphate–Adenosine Monophosphate Synthase (cGAS), a Multifaceted Platform of Intracellular DNA Sensing
por: Verrier, Eloi R., et al.
Publicado: (2021)

Treatment of Cardiovascular Dysfunction with PDE3-Inhibitors in Moderate and Severe Hypothermia—Effects on Cellular Elimination of Cyclic Adenosine Monophosphate and Cyclic Guanosine Monophosphate
por: Kuzmiszyn, Adrina Kalasho, et al.
Publicado: (2022)

In Search of Enzymes with a Role in 3′, 5′-Cyclic Guanosine Monophosphate Metabolism in Plants
por: Gross, Inonge, et al.
Publicado: (2016)

A Cyclic Guanosine Monophosphate–Dependent Pathway Can Regulate Net Hepatic Glucose Uptake in Vivo
por: An, Zhibo, et al.
Publicado: (2012)

Influence of calcium on guanosine 3',5'-cyclic monophosphate levels in frog rod outer segments
Publicado: (1981)

Cell Surface Protein Disulfide Isomerase Regulates Natriuretic Peptide Generation of Cyclic Guanosine Monophosphate
por: Pan, Shuchong, et al.
Publicado: (2014)

Involvement of Cyclic Guanosine Monophosphate-Dependent Protein Kinase I in Renal Antifibrotic Effects of Serelaxin
por: Wetzl, Veronika, et al.
Publicado: (2016)

Inhibition of hypoxia-inducible factor 1α accumulation by glyceryl trinitrate and cyclic guanosine monophosphate
por: Kim, Judy, et al.
Publicado: (2020)

Cyclic Guanosine Monophosphate and Risk of Incident Heart Failure and Other Cardiovascular Events: the ARIC Study
por: Zhao, Di, et al.
Publicado: (2020)

Regulation of the physiology and virulence of Ralstonia solanacearum by the second messenger 2′,3′-cyclic guanosine monophosphate
por: Li, Xia, et al.
Publicado: (2023)

Light-initiated changes of cyclic guanosine monophosphate levels in the frog retina measured with quick-freezing techniques
Publicado: (1979)

Effect of progesterone on nitric oxide/cyclic guanosine monophosphate signaling and contraction in gastric smooth muscle cells
por: Al-Shboul, Othman A, et al.
Publicado: (2020)

FRI669 Skeletal Effect Of Cyclic Guanosine Monophosphate Dependent Protein Kinase G Type 2
por: Kim, Se Min, et al.
Publicado: (2023)

The cyclic guanosine monophosphate synthase-stimulator of interferon genes pathway as a potential target for tumor immunotherapy
por: Chen, Rui, et al.
Publicado: (2023)

Temperature and pressure limits of guanosine monophosphate self-assemblies
por: Gao, Mimi, et al.
Publicado: (2017)

Phosphodiesterase 5 inhibitors lower both portal and pulmonary pressure in portopulmonary hypertension: a case report
por: Bremer, Hinrich C, et al.
Publicado: (2007)

Calcium effects on frog retinal cyclic guanosine 3’,5’- monophosphate levels and their light-initiated rate of decay
por: Kilbride, P
Publicado: (1980)

Cyclic Guanosine Monophosphate-Dependent Protein Kinase I Stimulators and Activators Are Therapeutic Alternatives for Sickle Cell Disease
por: Ghanta, Mohankrishna, et al.
Publicado: (2018)

Selective inhibition of intestinal guanosine 3′,5′-cyclic monophosphate signaling by small-molecule protein kinase inhibitors
por: Bijvelds, Marcel J. C., et al.
Publicado: (2018)

The endothelial nitric oxide synthase/cyclic guanosine monophosphate/protein kinase G pathway activates primordial follicles
por: Zhao, Peikun, et al.
Publicado: (2020)

Elongation factor P modulates Acinetobacter baumannii physiology and virulence as a cyclic dimeric guanosine monophosphate effector
por: Guo, Quan, et al.
Publicado: (2022)

Localization of putative binding sites for cyclic guanosine monophosphate and the anti-cancer drug 5-fluoro-2′-deoxyuridine-5′-monophosphate on ABCC11 in silico models
por: Honorat, Mylène, et al.
Publicado: (2013)

Rubus occidentalis and Ellagic Acid Affect the Contractility of Penile Corpus Cavernosum Smooth Muscle through the Nitric Oxide-Cyclic Guanosine Monophosphate and Cyclic Adenosine 3′,5′-Monophosphate Signaling Pathway
por: Karna, Keshab Kumar, et al.
Publicado: (2022)

Amplitude, kinetics, and reversibility of a light-induced decrease in guanosine 3',5'-cyclic monophosphate in frog photoreceptor membranes
Publicado: (1979)

Penile Erection Induced by Scoparone from Artemisia capillaris through the Nitric Oxide-Cyclic Guanosine Monophosphate Signaling Pathway
por: Choi, Bo Ram, et al.
Publicado: (2017)

The nitric oxide‐cyclic guanosine monophosphate pathway inhibits the bladder ATP release in response to a physiological or pathological stimulus
por: Okuyama, Eriko, et al.
Publicado: (2021)

Right ventricular and cyclic guanosine monophosphate signalling abnormalities in stages B and C of heart failure with preserved ejection fraction
por: Petit, Thibault, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_v6ot6k29fl18id7rt4tdcemhl2