Cargando…
Deformability-Based Electrokinetic Particle Separation
Deformability is an effective property that can be used in the separation of colloidal particles and cells. In this study, a microfluidic device is proposed and tested numerically for the sorting of deformable particles of various degrees. The separation process is numerically investigated by a dire...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189855/ https://www.ncbi.nlm.nih.gov/pubmed/30404343 http://dx.doi.org/10.3390/mi7090170 |
_version_ | 1783363447326507008 |
---|---|
author | Zhou, Teng Yeh, Li-Hsien Li, Feng-Chen Mauroy, Benjamin Joo, Sang Woo |
author_facet | Zhou, Teng Yeh, Li-Hsien Li, Feng-Chen Mauroy, Benjamin Joo, Sang Woo |
author_sort | Zhou, Teng |
collection | PubMed |
description | Deformability is an effective property that can be used in the separation of colloidal particles and cells. In this study, a microfluidic device is proposed and tested numerically for the sorting of deformable particles of various degrees. The separation process is numerically investigated by a direct numerical simulation of the fluid–particle–electric field interactions with an arbitrary Lagrangian–Eulerian finite-element method. The separation performance is investigated with the shear modulus of particles, the strength of the applied electric field, and the design of the contracted microfluidic devices as the main parameters. The results show that the particles with different shear moduli take different shapes and trajectories when passing through a microchannel contraction, enabling the separation of particles based on their difference in deformability. |
format | Online Article Text |
id | pubmed-6189855 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-61898552018-11-01 Deformability-Based Electrokinetic Particle Separation Zhou, Teng Yeh, Li-Hsien Li, Feng-Chen Mauroy, Benjamin Joo, Sang Woo Micromachines (Basel) Article Deformability is an effective property that can be used in the separation of colloidal particles and cells. In this study, a microfluidic device is proposed and tested numerically for the sorting of deformable particles of various degrees. The separation process is numerically investigated by a direct numerical simulation of the fluid–particle–electric field interactions with an arbitrary Lagrangian–Eulerian finite-element method. The separation performance is investigated with the shear modulus of particles, the strength of the applied electric field, and the design of the contracted microfluidic devices as the main parameters. The results show that the particles with different shear moduli take different shapes and trajectories when passing through a microchannel contraction, enabling the separation of particles based on their difference in deformability. MDPI 2016-09-20 /pmc/articles/PMC6189855/ /pubmed/30404343 http://dx.doi.org/10.3390/mi7090170 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Zhou, Teng Yeh, Li-Hsien Li, Feng-Chen Mauroy, Benjamin Joo, Sang Woo Deformability-Based Electrokinetic Particle Separation |
title | Deformability-Based Electrokinetic Particle Separation |
title_full | Deformability-Based Electrokinetic Particle Separation |
title_fullStr | Deformability-Based Electrokinetic Particle Separation |
title_full_unstemmed | Deformability-Based Electrokinetic Particle Separation |
title_short | Deformability-Based Electrokinetic Particle Separation |
title_sort | deformability-based electrokinetic particle separation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189855/ https://www.ncbi.nlm.nih.gov/pubmed/30404343 http://dx.doi.org/10.3390/mi7090170 |
work_keys_str_mv | AT zhouteng deformabilitybasedelectrokineticparticleseparation AT yehlihsien deformabilitybasedelectrokineticparticleseparation AT lifengchen deformabilitybasedelectrokineticparticleseparation AT mauroybenjamin deformabilitybasedelectrokineticparticleseparation AT joosangwoo deformabilitybasedelectrokineticparticleseparation |