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Universal Micromachining Platform and Basic Technologies for the Manufacture and Marking of Microphysiological Systems
Micro Physiological Systems (MPS), also known as Multi-Organ-Chip, Organ-on-a-Chip, or Body-on-a-Chip, are advanced microfluidic systems that allow the cultivation of different types of cells and tissue in just one common circuit. Furthermore, they thus can also adjust the interaction of these diffe...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189959/ https://www.ncbi.nlm.nih.gov/pubmed/30400437 http://dx.doi.org/10.3390/mi8080246 |
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author | Günther, Katja Sonntag, Frank Moritzer, Elmar Hirsch, Andrè Klotzbach, Udo Lasagni, Andrés Fabián |
author_facet | Günther, Katja Sonntag, Frank Moritzer, Elmar Hirsch, Andrè Klotzbach, Udo Lasagni, Andrés Fabián |
author_sort | Günther, Katja |
collection | PubMed |
description | Micro Physiological Systems (MPS), also known as Multi-Organ-Chip, Organ-on-a-Chip, or Body-on-a-Chip, are advanced microfluidic systems that allow the cultivation of different types of cells and tissue in just one common circuit. Furthermore, they thus can also adjust the interaction of these different tissues. Perspectival MPS will replace animal testing. For fast and flexible manufacturing and marking of MPS, a concept for a universal micromachining platform has been developed which provides the following latest key technologies: laser micro cutting of polymer foils, laser micro- and sub-micro-structuring of polymer foils, 3D printing of polymer components as well as optical inspection and online process control. The combination of different laser sources, processing optics, inspection systems, and print heads on multiple axes allows the change and exactly positioning to the workpiece during the process. Therewith, the realization of MPS including 3D printed components as well as direct laser interference patterned surfaces for well-defined cell adhesion and product protection is possible. Additional basic technologies for the generation of periodical line-like structures at polycarbonate foils using special Direct Laser Interference Patterning (DLIP) optics as well as for the 3D printing of fluid-tight cell culture reservoirs made of Acrylonitrile Butadiene Styrene directly onto polycarbonate microfluidics were established. A first prototype of the universal micromachining platform combining different lasers with Direct Laser Writing and DLIP is shown. With this laser micro cutting as well as laser micro-structuring of polycarbonate (PC) foils and therewith functionalization for MPS application could be successfully demonstrated. |
format | Online Article Text |
id | pubmed-6189959 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-61899592018-11-01 Universal Micromachining Platform and Basic Technologies for the Manufacture and Marking of Microphysiological Systems Günther, Katja Sonntag, Frank Moritzer, Elmar Hirsch, Andrè Klotzbach, Udo Lasagni, Andrés Fabián Micromachines (Basel) Article Micro Physiological Systems (MPS), also known as Multi-Organ-Chip, Organ-on-a-Chip, or Body-on-a-Chip, are advanced microfluidic systems that allow the cultivation of different types of cells and tissue in just one common circuit. Furthermore, they thus can also adjust the interaction of these different tissues. Perspectival MPS will replace animal testing. For fast and flexible manufacturing and marking of MPS, a concept for a universal micromachining platform has been developed which provides the following latest key technologies: laser micro cutting of polymer foils, laser micro- and sub-micro-structuring of polymer foils, 3D printing of polymer components as well as optical inspection and online process control. The combination of different laser sources, processing optics, inspection systems, and print heads on multiple axes allows the change and exactly positioning to the workpiece during the process. Therewith, the realization of MPS including 3D printed components as well as direct laser interference patterned surfaces for well-defined cell adhesion and product protection is possible. Additional basic technologies for the generation of periodical line-like structures at polycarbonate foils using special Direct Laser Interference Patterning (DLIP) optics as well as for the 3D printing of fluid-tight cell culture reservoirs made of Acrylonitrile Butadiene Styrene directly onto polycarbonate microfluidics were established. A first prototype of the universal micromachining platform combining different lasers with Direct Laser Writing and DLIP is shown. With this laser micro cutting as well as laser micro-structuring of polycarbonate (PC) foils and therewith functionalization for MPS application could be successfully demonstrated. MDPI 2017-08-11 /pmc/articles/PMC6189959/ /pubmed/30400437 http://dx.doi.org/10.3390/mi8080246 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Günther, Katja Sonntag, Frank Moritzer, Elmar Hirsch, Andrè Klotzbach, Udo Lasagni, Andrés Fabián Universal Micromachining Platform and Basic Technologies for the Manufacture and Marking of Microphysiological Systems |
title | Universal Micromachining Platform and Basic Technologies for the Manufacture and Marking of Microphysiological Systems |
title_full | Universal Micromachining Platform and Basic Technologies for the Manufacture and Marking of Microphysiological Systems |
title_fullStr | Universal Micromachining Platform and Basic Technologies for the Manufacture and Marking of Microphysiological Systems |
title_full_unstemmed | Universal Micromachining Platform and Basic Technologies for the Manufacture and Marking of Microphysiological Systems |
title_short | Universal Micromachining Platform and Basic Technologies for the Manufacture and Marking of Microphysiological Systems |
title_sort | universal micromachining platform and basic technologies for the manufacture and marking of microphysiological systems |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189959/ https://www.ncbi.nlm.nih.gov/pubmed/30400437 http://dx.doi.org/10.3390/mi8080246 |
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