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Fabrication of High-Aspect-Ratio 3D Hydrogel Microstructures Using Optically Induced Electrokinetics

We present a rapid hydrogel polymerization and prototyping microfabrication technique using an optically induced electrokinetics (OEK) chip, which is based on a non-UV hydrogel curing principle. Using this technique, micro-scale high-aspect-ratio three-dimensional polymer features with different geo...

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Autores principales: Li, Yi, Lai, Sam H. S., Liu, Na, Zhang, Guanglie, Liu, Lianqing, Lee, Gwo-Bin, Li, Wen Jung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189970/
https://www.ncbi.nlm.nih.gov/pubmed/30407438
http://dx.doi.org/10.3390/mi7040065
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author Li, Yi
Lai, Sam H. S.
Liu, Na
Zhang, Guanglie
Liu, Lianqing
Lee, Gwo-Bin
Li, Wen Jung
author_facet Li, Yi
Lai, Sam H. S.
Liu, Na
Zhang, Guanglie
Liu, Lianqing
Lee, Gwo-Bin
Li, Wen Jung
author_sort Li, Yi
collection PubMed
description We present a rapid hydrogel polymerization and prototyping microfabrication technique using an optically induced electrokinetics (OEK) chip, which is based on a non-UV hydrogel curing principle. Using this technique, micro-scale high-aspect-ratio three-dimensional polymer features with different geometric sizes can be fabricated within 1–10 min by projecting pre-defined visible light image patterns onto the OEK chip. This method eliminates the need for traditional photolithography masks used for patterning and fabricating polymer microstructures and simplifies the fabrication processes. This technique uses cross-link hydrogels, such as poly(ethylene glycol) (PEG)-diacrylate (PEGDA), as fabrication materials. We demonstrated that hydrogel micropillar arrays rapidly fabricated using this technique can be used as molds to create micron-scale cavities in PDMS (polydimethylsiloxane) substrates. Furthermore, hollow, circular tubes with controllable wall thicknesses and high-aspect ratios can also be fabricated. These results show the potential of this technique to become a rapid prototyping technology for producing microfluidic devices. In addition, we show that rapid prototyping of three-dimensional suspended polymer structures is possible without any sacrificial etching process.
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spelling pubmed-61899702018-11-01 Fabrication of High-Aspect-Ratio 3D Hydrogel Microstructures Using Optically Induced Electrokinetics Li, Yi Lai, Sam H. S. Liu, Na Zhang, Guanglie Liu, Lianqing Lee, Gwo-Bin Li, Wen Jung Micromachines (Basel) Article We present a rapid hydrogel polymerization and prototyping microfabrication technique using an optically induced electrokinetics (OEK) chip, which is based on a non-UV hydrogel curing principle. Using this technique, micro-scale high-aspect-ratio three-dimensional polymer features with different geometric sizes can be fabricated within 1–10 min by projecting pre-defined visible light image patterns onto the OEK chip. This method eliminates the need for traditional photolithography masks used for patterning and fabricating polymer microstructures and simplifies the fabrication processes. This technique uses cross-link hydrogels, such as poly(ethylene glycol) (PEG)-diacrylate (PEGDA), as fabrication materials. We demonstrated that hydrogel micropillar arrays rapidly fabricated using this technique can be used as molds to create micron-scale cavities in PDMS (polydimethylsiloxane) substrates. Furthermore, hollow, circular tubes with controllable wall thicknesses and high-aspect ratios can also be fabricated. These results show the potential of this technique to become a rapid prototyping technology for producing microfluidic devices. In addition, we show that rapid prototyping of three-dimensional suspended polymer structures is possible without any sacrificial etching process. MDPI 2016-04-12 /pmc/articles/PMC6189970/ /pubmed/30407438 http://dx.doi.org/10.3390/mi7040065 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Li, Yi
Lai, Sam H. S.
Liu, Na
Zhang, Guanglie
Liu, Lianqing
Lee, Gwo-Bin
Li, Wen Jung
Fabrication of High-Aspect-Ratio 3D Hydrogel Microstructures Using Optically Induced Electrokinetics
title Fabrication of High-Aspect-Ratio 3D Hydrogel Microstructures Using Optically Induced Electrokinetics
title_full Fabrication of High-Aspect-Ratio 3D Hydrogel Microstructures Using Optically Induced Electrokinetics
title_fullStr Fabrication of High-Aspect-Ratio 3D Hydrogel Microstructures Using Optically Induced Electrokinetics
title_full_unstemmed Fabrication of High-Aspect-Ratio 3D Hydrogel Microstructures Using Optically Induced Electrokinetics
title_short Fabrication of High-Aspect-Ratio 3D Hydrogel Microstructures Using Optically Induced Electrokinetics
title_sort fabrication of high-aspect-ratio 3d hydrogel microstructures using optically induced electrokinetics
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189970/
https://www.ncbi.nlm.nih.gov/pubmed/30407438
http://dx.doi.org/10.3390/mi7040065
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