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A Rapid Micromixer for Centrifugal Microfluidic Platforms
This paper presents an innovative mixing technology for centrifugal microfluidic platforms actuated using a specially designed flyball governor. The multilayer microfluidic disc was fabricated using a polydimethylsiloxane (PDMS) replica molding process with a soft lithography technique. The operatio...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189994/ https://www.ncbi.nlm.nih.gov/pubmed/30404263 http://dx.doi.org/10.3390/mi7050089 |
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author | Cai, Ziliang Xiang, Jiwen Chen, Hualing Wang, Wanjun |
author_facet | Cai, Ziliang Xiang, Jiwen Chen, Hualing Wang, Wanjun |
author_sort | Cai, Ziliang |
collection | PubMed |
description | This paper presents an innovative mixing technology for centrifugal microfluidic platforms actuated using a specially designed flyball governor. The multilayer microfluidic disc was fabricated using a polydimethylsiloxane (PDMS) replica molding process with a soft lithography technique. The operational principle is based on the interaction between the elastic covering membrane and an actuator pin installed on the flyball governor system. The flyball governor was used as the transducer to convert the rotary motion into a reciprocating linear motion of the pin pressing against the covering membrane of the mixer chamber. When the rotation speed of the microfluidic disc was periodically altered, the mixing chamber was compressed and released accordingly. In this way, enhanced active mixing can be achieved with much better efficiency in comparison with diffusive mixing. |
format | Online Article Text |
id | pubmed-6189994 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-61899942018-11-01 A Rapid Micromixer for Centrifugal Microfluidic Platforms Cai, Ziliang Xiang, Jiwen Chen, Hualing Wang, Wanjun Micromachines (Basel) Article This paper presents an innovative mixing technology for centrifugal microfluidic platforms actuated using a specially designed flyball governor. The multilayer microfluidic disc was fabricated using a polydimethylsiloxane (PDMS) replica molding process with a soft lithography technique. The operational principle is based on the interaction between the elastic covering membrane and an actuator pin installed on the flyball governor system. The flyball governor was used as the transducer to convert the rotary motion into a reciprocating linear motion of the pin pressing against the covering membrane of the mixer chamber. When the rotation speed of the microfluidic disc was periodically altered, the mixing chamber was compressed and released accordingly. In this way, enhanced active mixing can be achieved with much better efficiency in comparison with diffusive mixing. MDPI 2016-05-10 /pmc/articles/PMC6189994/ /pubmed/30404263 http://dx.doi.org/10.3390/mi7050089 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Cai, Ziliang Xiang, Jiwen Chen, Hualing Wang, Wanjun A Rapid Micromixer for Centrifugal Microfluidic Platforms |
title | A Rapid Micromixer for Centrifugal Microfluidic Platforms |
title_full | A Rapid Micromixer for Centrifugal Microfluidic Platforms |
title_fullStr | A Rapid Micromixer for Centrifugal Microfluidic Platforms |
title_full_unstemmed | A Rapid Micromixer for Centrifugal Microfluidic Platforms |
title_short | A Rapid Micromixer for Centrifugal Microfluidic Platforms |
title_sort | rapid micromixer for centrifugal microfluidic platforms |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189994/ https://www.ncbi.nlm.nih.gov/pubmed/30404263 http://dx.doi.org/10.3390/mi7050089 |
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