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A Rapid Micromixer for Centrifugal Microfluidic Platforms

This paper presents an innovative mixing technology for centrifugal microfluidic platforms actuated using a specially designed flyball governor. The multilayer microfluidic disc was fabricated using a polydimethylsiloxane (PDMS) replica molding process with a soft lithography technique. The operatio...

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Detalles Bibliográficos
Autores principales: Cai, Ziliang, Xiang, Jiwen, Chen, Hualing, Wang, Wanjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189994/
https://www.ncbi.nlm.nih.gov/pubmed/30404263
http://dx.doi.org/10.3390/mi7050089
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author Cai, Ziliang
Xiang, Jiwen
Chen, Hualing
Wang, Wanjun
author_facet Cai, Ziliang
Xiang, Jiwen
Chen, Hualing
Wang, Wanjun
author_sort Cai, Ziliang
collection PubMed
description This paper presents an innovative mixing technology for centrifugal microfluidic platforms actuated using a specially designed flyball governor. The multilayer microfluidic disc was fabricated using a polydimethylsiloxane (PDMS) replica molding process with a soft lithography technique. The operational principle is based on the interaction between the elastic covering membrane and an actuator pin installed on the flyball governor system. The flyball governor was used as the transducer to convert the rotary motion into a reciprocating linear motion of the pin pressing against the covering membrane of the mixer chamber. When the rotation speed of the microfluidic disc was periodically altered, the mixing chamber was compressed and released accordingly. In this way, enhanced active mixing can be achieved with much better efficiency in comparison with diffusive mixing.
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spelling pubmed-61899942018-11-01 A Rapid Micromixer for Centrifugal Microfluidic Platforms Cai, Ziliang Xiang, Jiwen Chen, Hualing Wang, Wanjun Micromachines (Basel) Article This paper presents an innovative mixing technology for centrifugal microfluidic platforms actuated using a specially designed flyball governor. The multilayer microfluidic disc was fabricated using a polydimethylsiloxane (PDMS) replica molding process with a soft lithography technique. The operational principle is based on the interaction between the elastic covering membrane and an actuator pin installed on the flyball governor system. The flyball governor was used as the transducer to convert the rotary motion into a reciprocating linear motion of the pin pressing against the covering membrane of the mixer chamber. When the rotation speed of the microfluidic disc was periodically altered, the mixing chamber was compressed and released accordingly. In this way, enhanced active mixing can be achieved with much better efficiency in comparison with diffusive mixing. MDPI 2016-05-10 /pmc/articles/PMC6189994/ /pubmed/30404263 http://dx.doi.org/10.3390/mi7050089 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cai, Ziliang
Xiang, Jiwen
Chen, Hualing
Wang, Wanjun
A Rapid Micromixer for Centrifugal Microfluidic Platforms
title A Rapid Micromixer for Centrifugal Microfluidic Platforms
title_full A Rapid Micromixer for Centrifugal Microfluidic Platforms
title_fullStr A Rapid Micromixer for Centrifugal Microfluidic Platforms
title_full_unstemmed A Rapid Micromixer for Centrifugal Microfluidic Platforms
title_short A Rapid Micromixer for Centrifugal Microfluidic Platforms
title_sort rapid micromixer for centrifugal microfluidic platforms
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189994/
https://www.ncbi.nlm.nih.gov/pubmed/30404263
http://dx.doi.org/10.3390/mi7050089
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