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Visualization Study of Oil-in-Water-in-Oil (O/W/O) Double Emulsion Formation in a Simple and Robust Co-Flowing Microfluidic Device

A simple and robust co-flowing microfluidic device for double emulsion preparation is designed and assembled to visually study the double emulsion formation by the use of a microscope and high-speed camera. Using a visualization system, the transient processes of double emulsion formation in co-flow...

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Detalles Bibliográficos
Autores principales: Lu, Pengfei, Wu, Liangyu, Liu, Xiangdong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6190057/
https://www.ncbi.nlm.nih.gov/pubmed/30400458
http://dx.doi.org/10.3390/mi8090268
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author Lu, Pengfei
Wu, Liangyu
Liu, Xiangdong
author_facet Lu, Pengfei
Wu, Liangyu
Liu, Xiangdong
author_sort Lu, Pengfei
collection PubMed
description A simple and robust co-flowing microfluidic device for double emulsion preparation is designed and assembled to visually study the double emulsion formation by the use of a microscope and high-speed camera. Using a visualization system, the transient processes of double emulsion formation in co-flowing stream are observed and recorded for a variety of flow rates. The effects of flow rates of each fluid on flow modes, drop sizes, and polydispersities are examined and analyzed. The results indicate that the detaching of the inner drops accelerates the detaching of the outer drops and speeds up the drop formation process of double emulsions. The manipulation of flow rates is capable to actively control the sizes of the inner and outer drops as well as the number of inner drops encapsulated. Without surface modification, the microfluidic device produces a variety of emulsions, including the single-core and multi-core O/W/O double emulsions as well as binary emulsions of single and double emulsions. The proposed co-flowing microfluidic device is highly desirable in producing double emulsions in an easy and cheap way.
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spelling pubmed-61900572018-11-01 Visualization Study of Oil-in-Water-in-Oil (O/W/O) Double Emulsion Formation in a Simple and Robust Co-Flowing Microfluidic Device Lu, Pengfei Wu, Liangyu Liu, Xiangdong Micromachines (Basel) Article A simple and robust co-flowing microfluidic device for double emulsion preparation is designed and assembled to visually study the double emulsion formation by the use of a microscope and high-speed camera. Using a visualization system, the transient processes of double emulsion formation in co-flowing stream are observed and recorded for a variety of flow rates. The effects of flow rates of each fluid on flow modes, drop sizes, and polydispersities are examined and analyzed. The results indicate that the detaching of the inner drops accelerates the detaching of the outer drops and speeds up the drop formation process of double emulsions. The manipulation of flow rates is capable to actively control the sizes of the inner and outer drops as well as the number of inner drops encapsulated. Without surface modification, the microfluidic device produces a variety of emulsions, including the single-core and multi-core O/W/O double emulsions as well as binary emulsions of single and double emulsions. The proposed co-flowing microfluidic device is highly desirable in producing double emulsions in an easy and cheap way. MDPI 2017-09-01 /pmc/articles/PMC6190057/ /pubmed/30400458 http://dx.doi.org/10.3390/mi8090268 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lu, Pengfei
Wu, Liangyu
Liu, Xiangdong
Visualization Study of Oil-in-Water-in-Oil (O/W/O) Double Emulsion Formation in a Simple and Robust Co-Flowing Microfluidic Device
title Visualization Study of Oil-in-Water-in-Oil (O/W/O) Double Emulsion Formation in a Simple and Robust Co-Flowing Microfluidic Device
title_full Visualization Study of Oil-in-Water-in-Oil (O/W/O) Double Emulsion Formation in a Simple and Robust Co-Flowing Microfluidic Device
title_fullStr Visualization Study of Oil-in-Water-in-Oil (O/W/O) Double Emulsion Formation in a Simple and Robust Co-Flowing Microfluidic Device
title_full_unstemmed Visualization Study of Oil-in-Water-in-Oil (O/W/O) Double Emulsion Formation in a Simple and Robust Co-Flowing Microfluidic Device
title_short Visualization Study of Oil-in-Water-in-Oil (O/W/O) Double Emulsion Formation in a Simple and Robust Co-Flowing Microfluidic Device
title_sort visualization study of oil-in-water-in-oil (o/w/o) double emulsion formation in a simple and robust co-flowing microfluidic device
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6190057/
https://www.ncbi.nlm.nih.gov/pubmed/30400458
http://dx.doi.org/10.3390/mi8090268
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