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High-Pressure Acceleration of Nanoliter Droplets in the Gas Phase in a Microchannel
Microfluidics has been used to perform various chemical operations for pL–nL volumes of samples, such as mixing, reaction and separation, by exploiting diffusion, viscous forces, and surface tension, which are dominant in spaces with dimensions on the micrometer scale. To further develop this field,...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6190114/ https://www.ncbi.nlm.nih.gov/pubmed/30404314 http://dx.doi.org/10.3390/mi7080142 |
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author | Kazoe, Yutaka Yamashiro, Ippei Mawatari, Kazuma Kitamori, Takehiko |
author_facet | Kazoe, Yutaka Yamashiro, Ippei Mawatari, Kazuma Kitamori, Takehiko |
author_sort | Kazoe, Yutaka |
collection | PubMed |
description | Microfluidics has been used to perform various chemical operations for pL–nL volumes of samples, such as mixing, reaction and separation, by exploiting diffusion, viscous forces, and surface tension, which are dominant in spaces with dimensions on the micrometer scale. To further develop this field, we previously developed a novel microfluidic device, termed a microdroplet collider, which exploits spatially and temporally localized kinetic energy. This device accelerates a microdroplet in the gas phase along a microchannel until it collides with a target. We demonstrated 6000-fold faster mixing compared to mixing by diffusion; however, the droplet acceleration was not optimized, because the experiments were conducted for only one droplet size and at pressures in the 10–100 kPa range. In this study, we investigated the acceleration of a microdroplet using a high-pressure (MPa) control system, in order to achieve higher acceleration and kinetic energy. The motion of the nL droplet was observed using a high-speed complementary metal oxide semiconductor (CMOS) camera. A maximum droplet velocity of ~5 m/s was achieved at a pressure of 1–2 MPa. Despite the higher fluid resistance, longer droplets yielded higher acceleration and kinetic energy, because droplet splitting was a determining factor in the acceleration and using a longer droplet helped prevent it. The results provide design guidelines for achieving higher kinetic energies in the microdroplet collider for various microfluidic applications. |
format | Online Article Text |
id | pubmed-6190114 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-61901142018-11-01 High-Pressure Acceleration of Nanoliter Droplets in the Gas Phase in a Microchannel Kazoe, Yutaka Yamashiro, Ippei Mawatari, Kazuma Kitamori, Takehiko Micromachines (Basel) Article Microfluidics has been used to perform various chemical operations for pL–nL volumes of samples, such as mixing, reaction and separation, by exploiting diffusion, viscous forces, and surface tension, which are dominant in spaces with dimensions on the micrometer scale. To further develop this field, we previously developed a novel microfluidic device, termed a microdroplet collider, which exploits spatially and temporally localized kinetic energy. This device accelerates a microdroplet in the gas phase along a microchannel until it collides with a target. We demonstrated 6000-fold faster mixing compared to mixing by diffusion; however, the droplet acceleration was not optimized, because the experiments were conducted for only one droplet size and at pressures in the 10–100 kPa range. In this study, we investigated the acceleration of a microdroplet using a high-pressure (MPa) control system, in order to achieve higher acceleration and kinetic energy. The motion of the nL droplet was observed using a high-speed complementary metal oxide semiconductor (CMOS) camera. A maximum droplet velocity of ~5 m/s was achieved at a pressure of 1–2 MPa. Despite the higher fluid resistance, longer droplets yielded higher acceleration and kinetic energy, because droplet splitting was a determining factor in the acceleration and using a longer droplet helped prevent it. The results provide design guidelines for achieving higher kinetic energies in the microdroplet collider for various microfluidic applications. MDPI 2016-08-15 /pmc/articles/PMC6190114/ /pubmed/30404314 http://dx.doi.org/10.3390/mi7080142 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kazoe, Yutaka Yamashiro, Ippei Mawatari, Kazuma Kitamori, Takehiko High-Pressure Acceleration of Nanoliter Droplets in the Gas Phase in a Microchannel |
title | High-Pressure Acceleration of Nanoliter Droplets in the Gas Phase in a Microchannel |
title_full | High-Pressure Acceleration of Nanoliter Droplets in the Gas Phase in a Microchannel |
title_fullStr | High-Pressure Acceleration of Nanoliter Droplets in the Gas Phase in a Microchannel |
title_full_unstemmed | High-Pressure Acceleration of Nanoliter Droplets in the Gas Phase in a Microchannel |
title_short | High-Pressure Acceleration of Nanoliter Droplets in the Gas Phase in a Microchannel |
title_sort | high-pressure acceleration of nanoliter droplets in the gas phase in a microchannel |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6190114/ https://www.ncbi.nlm.nih.gov/pubmed/30404314 http://dx.doi.org/10.3390/mi7080142 |
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