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Heterologous effects of infant BCG vaccination: potential mechanisms of immunity
The current antituberculosis vaccine, BCG, was derived in the 1920s, yet the mechanisms of BCG-induced protective immunity and the variability of protective efficacy among populations are still not fully understood. BCG challenges the concept of vaccine specificity, as there is evidence that BCG may...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Future Medicine Ltd
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6190278/ https://www.ncbi.nlm.nih.gov/pubmed/30117744 http://dx.doi.org/10.2217/fmb-2018-0026 |
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author | Butkeviciute, Egle Jones, Christine E Smith, Steven G |
author_facet | Butkeviciute, Egle Jones, Christine E Smith, Steven G |
author_sort | Butkeviciute, Egle |
collection | PubMed |
description | The current antituberculosis vaccine, BCG, was derived in the 1920s, yet the mechanisms of BCG-induced protective immunity and the variability of protective efficacy among populations are still not fully understood. BCG challenges the concept of vaccine specificity, as there is evidence that BCG may protect immunized infants from pathogens other than Mycobacterium tuberculosis – resulting in heterologous or nonspecific protection. This review summarizes the up-to-date evidence for this phenomenon, potential immunological mechanisms and implications for improved childhood vaccine design. BCG induces functional changes in infant innate and adaptive immune compartments, encouraging their collaboration in the first year of life. Understanding biological mechanisms beyond heterologous BCG effects is crucial to improve infant protection from infectious diseases. |
format | Online Article Text |
id | pubmed-6190278 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Future Medicine Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-61902782018-10-19 Heterologous effects of infant BCG vaccination: potential mechanisms of immunity Butkeviciute, Egle Jones, Christine E Smith, Steven G Future Microbiol Review The current antituberculosis vaccine, BCG, was derived in the 1920s, yet the mechanisms of BCG-induced protective immunity and the variability of protective efficacy among populations are still not fully understood. BCG challenges the concept of vaccine specificity, as there is evidence that BCG may protect immunized infants from pathogens other than Mycobacterium tuberculosis – resulting in heterologous or nonspecific protection. This review summarizes the up-to-date evidence for this phenomenon, potential immunological mechanisms and implications for improved childhood vaccine design. BCG induces functional changes in infant innate and adaptive immune compartments, encouraging their collaboration in the first year of life. Understanding biological mechanisms beyond heterologous BCG effects is crucial to improve infant protection from infectious diseases. Future Medicine Ltd 2018-08 2018-08-17 /pmc/articles/PMC6190278/ /pubmed/30117744 http://dx.doi.org/10.2217/fmb-2018-0026 Text en © 2018 Dr Steven G Smith This work is licensed under the Attribution-NonCommercial-NoDerivatives 4.0 Unported License (http://creativecommons.org/licenses/by-nc-nd/4.0/) |
spellingShingle | Review Butkeviciute, Egle Jones, Christine E Smith, Steven G Heterologous effects of infant BCG vaccination: potential mechanisms of immunity |
title | Heterologous effects of infant BCG vaccination: potential mechanisms of immunity |
title_full | Heterologous effects of infant BCG vaccination: potential mechanisms of immunity |
title_fullStr | Heterologous effects of infant BCG vaccination: potential mechanisms of immunity |
title_full_unstemmed | Heterologous effects of infant BCG vaccination: potential mechanisms of immunity |
title_short | Heterologous effects of infant BCG vaccination: potential mechanisms of immunity |
title_sort | heterologous effects of infant bcg vaccination: potential mechanisms of immunity |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6190278/ https://www.ncbi.nlm.nih.gov/pubmed/30117744 http://dx.doi.org/10.2217/fmb-2018-0026 |
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