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3D Printing of Artificial Blood Vessel: Study on Multi-Parameter Optimization Design for Vascular Molding Effect in Alginate and Gelatin

3D printing has emerged as one of the modern tissue engineering techniques that could potentially form scaffolds (with or without cells), which is useful in treating cardiovascular diseases. This technology has attracted extensive attention due to its possibility of curing disease in tissue engineer...

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Detalles Bibliográficos
Autores principales: Liu, Huanbao, Zhou, Huixing, Lan, Haiming, Liu, Tianyu, Liu, Xiaolong, Yu, Hejie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6190318/
https://www.ncbi.nlm.nih.gov/pubmed/30400427
http://dx.doi.org/10.3390/mi8080237
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author Liu, Huanbao
Zhou, Huixing
Lan, Haiming
Liu, Tianyu
Liu, Xiaolong
Yu, Hejie
author_facet Liu, Huanbao
Zhou, Huixing
Lan, Haiming
Liu, Tianyu
Liu, Xiaolong
Yu, Hejie
author_sort Liu, Huanbao
collection PubMed
description 3D printing has emerged as one of the modern tissue engineering techniques that could potentially form scaffolds (with or without cells), which is useful in treating cardiovascular diseases. This technology has attracted extensive attention due to its possibility of curing disease in tissue engineering and organ regeneration. In this paper, we have developed a novel rotary forming device, prepared an alginate–gelatin solution for the fabrication of vessel-like structures, and further proposed a theoretical model to analyze the parameters of motion synchronization. Using this rotary forming device, we firstly establish a theoretical model to analyze the thickness under the different nozzle extrusion speeds, nozzle speeds, and servo motor speeds. Secondly, the experiments with alginate–gelatin solution are carried out to construct the vessel-like structures under all sorts of conditions. The experiment results show that the thickness cannot be adequately predicted by the theoretical model and the thickness can be controlled by changing the parameters. Finally, the optimized parameters of thickness have been adjusted to estimate the real thickness in 3D printing.
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spelling pubmed-61903182018-11-01 3D Printing of Artificial Blood Vessel: Study on Multi-Parameter Optimization Design for Vascular Molding Effect in Alginate and Gelatin Liu, Huanbao Zhou, Huixing Lan, Haiming Liu, Tianyu Liu, Xiaolong Yu, Hejie Micromachines (Basel) Article 3D printing has emerged as one of the modern tissue engineering techniques that could potentially form scaffolds (with or without cells), which is useful in treating cardiovascular diseases. This technology has attracted extensive attention due to its possibility of curing disease in tissue engineering and organ regeneration. In this paper, we have developed a novel rotary forming device, prepared an alginate–gelatin solution for the fabrication of vessel-like structures, and further proposed a theoretical model to analyze the parameters of motion synchronization. Using this rotary forming device, we firstly establish a theoretical model to analyze the thickness under the different nozzle extrusion speeds, nozzle speeds, and servo motor speeds. Secondly, the experiments with alginate–gelatin solution are carried out to construct the vessel-like structures under all sorts of conditions. The experiment results show that the thickness cannot be adequately predicted by the theoretical model and the thickness can be controlled by changing the parameters. Finally, the optimized parameters of thickness have been adjusted to estimate the real thickness in 3D printing. MDPI 2017-07-31 /pmc/articles/PMC6190318/ /pubmed/30400427 http://dx.doi.org/10.3390/mi8080237 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Liu, Huanbao
Zhou, Huixing
Lan, Haiming
Liu, Tianyu
Liu, Xiaolong
Yu, Hejie
3D Printing of Artificial Blood Vessel: Study on Multi-Parameter Optimization Design for Vascular Molding Effect in Alginate and Gelatin
title 3D Printing of Artificial Blood Vessel: Study on Multi-Parameter Optimization Design for Vascular Molding Effect in Alginate and Gelatin
title_full 3D Printing of Artificial Blood Vessel: Study on Multi-Parameter Optimization Design for Vascular Molding Effect in Alginate and Gelatin
title_fullStr 3D Printing of Artificial Blood Vessel: Study on Multi-Parameter Optimization Design for Vascular Molding Effect in Alginate and Gelatin
title_full_unstemmed 3D Printing of Artificial Blood Vessel: Study on Multi-Parameter Optimization Design for Vascular Molding Effect in Alginate and Gelatin
title_short 3D Printing of Artificial Blood Vessel: Study on Multi-Parameter Optimization Design for Vascular Molding Effect in Alginate and Gelatin
title_sort 3d printing of artificial blood vessel: study on multi-parameter optimization design for vascular molding effect in alginate and gelatin
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6190318/
https://www.ncbi.nlm.nih.gov/pubmed/30400427
http://dx.doi.org/10.3390/mi8080237
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