Label-Free Monitoring of Diffusion in Microfluidics

Label-free, real-time detection of concentration gradients is demonstrated in a microfluidic H-filter, using an integrated photonic crystal slab sensor to monitor sample refractive index with spatial resolution. The recorded diffusion profiles reveal root-mean-square diffusion lengths for non-fluore...

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Detalles Bibliográficos
Autores principales: Tølbøl Sørensen, Kristian, Kristensen, Anders
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6190349/
https://www.ncbi.nlm.nih.gov/pubmed/30400519
http://dx.doi.org/10.3390/mi8110329
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author Tølbøl Sørensen, Kristian
Kristensen, Anders
author_facet Tølbøl Sørensen, Kristian
Kristensen, Anders
author_sort Tølbøl Sørensen, Kristian
collection PubMed
description Label-free, real-time detection of concentration gradients is demonstrated in a microfluidic H-filter, using an integrated photonic crystal slab sensor to monitor sample refractive index with spatial resolution. The recorded diffusion profiles reveal root-mean-square diffusion lengths for non-fluorescing and non-absorbing molecules, both small (glucose, 180 Da) and large (bovine serum albumin, 67 kDa).
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spelling pubmed-61903492018-11-01 Label-Free Monitoring of Diffusion in Microfluidics Tølbøl Sørensen, Kristian Kristensen, Anders Micromachines (Basel) Article Label-free, real-time detection of concentration gradients is demonstrated in a microfluidic H-filter, using an integrated photonic crystal slab sensor to monitor sample refractive index with spatial resolution. The recorded diffusion profiles reveal root-mean-square diffusion lengths for non-fluorescing and non-absorbing molecules, both small (glucose, 180 Da) and large (bovine serum albumin, 67 kDa). MDPI 2017-11-09 /pmc/articles/PMC6190349/ /pubmed/30400519 http://dx.doi.org/10.3390/mi8110329 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tølbøl Sørensen, Kristian
Kristensen, Anders
Label-Free Monitoring of Diffusion in Microfluidics
title Label-Free Monitoring of Diffusion in Microfluidics
title_full Label-Free Monitoring of Diffusion in Microfluidics
title_fullStr Label-Free Monitoring of Diffusion in Microfluidics
title_full_unstemmed Label-Free Monitoring of Diffusion in Microfluidics
title_short Label-Free Monitoring of Diffusion in Microfluidics
title_sort label-free monitoring of diffusion in microfluidics
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6190349/
https://www.ncbi.nlm.nih.gov/pubmed/30400519
http://dx.doi.org/10.3390/mi8110329
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