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Rapid Prototyping of Plastic Lab-on-a-Chip by Femtosecond Laser Micromachining and Removable Insert Microinjection Molding

We have introduced a new hybrid fabrication method for lab-on-a-chip devices through the combination of femtosecond laser micromachining and removable insert micro-injection molding. This method is particularly suited for the fast prototyping of new devices, while maintaining a competitive low cost....

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Detalles Bibliográficos
Autores principales: Martínez Vázquez, Rebeca, Trotta, Gianluca, Volpe, Annalisa, Bernava, Giuseppe, Basile, Vito, Paturzo, Melania, Ferraro, Pietro, Ancona, Antonio, Fassi, Irene, Osellame, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6190455/
https://www.ncbi.nlm.nih.gov/pubmed/30400518
http://dx.doi.org/10.3390/mi8110328
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author Martínez Vázquez, Rebeca
Trotta, Gianluca
Volpe, Annalisa
Bernava, Giuseppe
Basile, Vito
Paturzo, Melania
Ferraro, Pietro
Ancona, Antonio
Fassi, Irene
Osellame, Roberto
author_facet Martínez Vázquez, Rebeca
Trotta, Gianluca
Volpe, Annalisa
Bernava, Giuseppe
Basile, Vito
Paturzo, Melania
Ferraro, Pietro
Ancona, Antonio
Fassi, Irene
Osellame, Roberto
author_sort Martínez Vázquez, Rebeca
collection PubMed
description We have introduced a new hybrid fabrication method for lab-on-a-chip devices through the combination of femtosecond laser micromachining and removable insert micro-injection molding. This method is particularly suited for the fast prototyping of new devices, while maintaining a competitive low cost. To demonstrate the effectiveness of our approach, we designed, fabricated, and tested a completely integrated flow cytometer coupled to a portable media device. The system operation was tested with fluorescent plastic micro-bead solutions ranging from 100 beads/μL to 500 beads/μL. We demonstrated that this hybrid lab-on-a-chip fabrication technology is suitable for producing low-cost and portable biological microsystems and for effectively bridging the gap between new device concepts and their mass production.
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spelling pubmed-61904552018-11-01 Rapid Prototyping of Plastic Lab-on-a-Chip by Femtosecond Laser Micromachining and Removable Insert Microinjection Molding Martínez Vázquez, Rebeca Trotta, Gianluca Volpe, Annalisa Bernava, Giuseppe Basile, Vito Paturzo, Melania Ferraro, Pietro Ancona, Antonio Fassi, Irene Osellame, Roberto Micromachines (Basel) Article We have introduced a new hybrid fabrication method for lab-on-a-chip devices through the combination of femtosecond laser micromachining and removable insert micro-injection molding. This method is particularly suited for the fast prototyping of new devices, while maintaining a competitive low cost. To demonstrate the effectiveness of our approach, we designed, fabricated, and tested a completely integrated flow cytometer coupled to a portable media device. The system operation was tested with fluorescent plastic micro-bead solutions ranging from 100 beads/μL to 500 beads/μL. We demonstrated that this hybrid lab-on-a-chip fabrication technology is suitable for producing low-cost and portable biological microsystems and for effectively bridging the gap between new device concepts and their mass production. MDPI 2017-11-07 /pmc/articles/PMC6190455/ /pubmed/30400518 http://dx.doi.org/10.3390/mi8110328 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Martínez Vázquez, Rebeca
Trotta, Gianluca
Volpe, Annalisa
Bernava, Giuseppe
Basile, Vito
Paturzo, Melania
Ferraro, Pietro
Ancona, Antonio
Fassi, Irene
Osellame, Roberto
Rapid Prototyping of Plastic Lab-on-a-Chip by Femtosecond Laser Micromachining and Removable Insert Microinjection Molding
title Rapid Prototyping of Plastic Lab-on-a-Chip by Femtosecond Laser Micromachining and Removable Insert Microinjection Molding
title_full Rapid Prototyping of Plastic Lab-on-a-Chip by Femtosecond Laser Micromachining and Removable Insert Microinjection Molding
title_fullStr Rapid Prototyping of Plastic Lab-on-a-Chip by Femtosecond Laser Micromachining and Removable Insert Microinjection Molding
title_full_unstemmed Rapid Prototyping of Plastic Lab-on-a-Chip by Femtosecond Laser Micromachining and Removable Insert Microinjection Molding
title_short Rapid Prototyping of Plastic Lab-on-a-Chip by Femtosecond Laser Micromachining and Removable Insert Microinjection Molding
title_sort rapid prototyping of plastic lab-on-a-chip by femtosecond laser micromachining and removable insert microinjection molding
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6190455/
https://www.ncbi.nlm.nih.gov/pubmed/30400518
http://dx.doi.org/10.3390/mi8110328
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