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Rapid Prototyping of Plastic Lab-on-a-Chip by Femtosecond Laser Micromachining and Removable Insert Microinjection Molding
We have introduced a new hybrid fabrication method for lab-on-a-chip devices through the combination of femtosecond laser micromachining and removable insert micro-injection molding. This method is particularly suited for the fast prototyping of new devices, while maintaining a competitive low cost....
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6190455/ https://www.ncbi.nlm.nih.gov/pubmed/30400518 http://dx.doi.org/10.3390/mi8110328 |
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author | Martínez Vázquez, Rebeca Trotta, Gianluca Volpe, Annalisa Bernava, Giuseppe Basile, Vito Paturzo, Melania Ferraro, Pietro Ancona, Antonio Fassi, Irene Osellame, Roberto |
author_facet | Martínez Vázquez, Rebeca Trotta, Gianluca Volpe, Annalisa Bernava, Giuseppe Basile, Vito Paturzo, Melania Ferraro, Pietro Ancona, Antonio Fassi, Irene Osellame, Roberto |
author_sort | Martínez Vázquez, Rebeca |
collection | PubMed |
description | We have introduced a new hybrid fabrication method for lab-on-a-chip devices through the combination of femtosecond laser micromachining and removable insert micro-injection molding. This method is particularly suited for the fast prototyping of new devices, while maintaining a competitive low cost. To demonstrate the effectiveness of our approach, we designed, fabricated, and tested a completely integrated flow cytometer coupled to a portable media device. The system operation was tested with fluorescent plastic micro-bead solutions ranging from 100 beads/μL to 500 beads/μL. We demonstrated that this hybrid lab-on-a-chip fabrication technology is suitable for producing low-cost and portable biological microsystems and for effectively bridging the gap between new device concepts and their mass production. |
format | Online Article Text |
id | pubmed-6190455 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-61904552018-11-01 Rapid Prototyping of Plastic Lab-on-a-Chip by Femtosecond Laser Micromachining and Removable Insert Microinjection Molding Martínez Vázquez, Rebeca Trotta, Gianluca Volpe, Annalisa Bernava, Giuseppe Basile, Vito Paturzo, Melania Ferraro, Pietro Ancona, Antonio Fassi, Irene Osellame, Roberto Micromachines (Basel) Article We have introduced a new hybrid fabrication method for lab-on-a-chip devices through the combination of femtosecond laser micromachining and removable insert micro-injection molding. This method is particularly suited for the fast prototyping of new devices, while maintaining a competitive low cost. To demonstrate the effectiveness of our approach, we designed, fabricated, and tested a completely integrated flow cytometer coupled to a portable media device. The system operation was tested with fluorescent plastic micro-bead solutions ranging from 100 beads/μL to 500 beads/μL. We demonstrated that this hybrid lab-on-a-chip fabrication technology is suitable for producing low-cost and portable biological microsystems and for effectively bridging the gap between new device concepts and their mass production. MDPI 2017-11-07 /pmc/articles/PMC6190455/ /pubmed/30400518 http://dx.doi.org/10.3390/mi8110328 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Martínez Vázquez, Rebeca Trotta, Gianluca Volpe, Annalisa Bernava, Giuseppe Basile, Vito Paturzo, Melania Ferraro, Pietro Ancona, Antonio Fassi, Irene Osellame, Roberto Rapid Prototyping of Plastic Lab-on-a-Chip by Femtosecond Laser Micromachining and Removable Insert Microinjection Molding |
title | Rapid Prototyping of Plastic Lab-on-a-Chip by Femtosecond Laser Micromachining and Removable Insert Microinjection Molding |
title_full | Rapid Prototyping of Plastic Lab-on-a-Chip by Femtosecond Laser Micromachining and Removable Insert Microinjection Molding |
title_fullStr | Rapid Prototyping of Plastic Lab-on-a-Chip by Femtosecond Laser Micromachining and Removable Insert Microinjection Molding |
title_full_unstemmed | Rapid Prototyping of Plastic Lab-on-a-Chip by Femtosecond Laser Micromachining and Removable Insert Microinjection Molding |
title_short | Rapid Prototyping of Plastic Lab-on-a-Chip by Femtosecond Laser Micromachining and Removable Insert Microinjection Molding |
title_sort | rapid prototyping of plastic lab-on-a-chip by femtosecond laser micromachining and removable insert microinjection molding |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6190455/ https://www.ncbi.nlm.nih.gov/pubmed/30400518 http://dx.doi.org/10.3390/mi8110328 |
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