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P3H4 is correlated with clinicopathological features and prognosis in bladder cancer
BACKGROUND: Genetic alterations play a significant role in the progression of bladder cancer. Identifying novel biomarkers to personalize the therapeutic regimen and evaluate the prognosis of patients with bladder cancer is vital. Prolyl 3-hydroxylase family member 4 (P3H4) is significantly involved...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6190559/ https://www.ncbi.nlm.nih.gov/pubmed/30322400 http://dx.doi.org/10.1186/s12957-018-1507-2 |
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author | Li, Wangjian Ye, Lihong Chen, Yongliang Chen, Peng |
author_facet | Li, Wangjian Ye, Lihong Chen, Yongliang Chen, Peng |
author_sort | Li, Wangjian |
collection | PubMed |
description | BACKGROUND: Genetic alterations play a significant role in the progression of bladder cancer. Identifying novel biomarkers to personalize the therapeutic regimen and evaluate the prognosis of patients with bladder cancer is vital. Prolyl 3-hydroxylase family member 4 (P3H4) is significantly involved in several types of human cancer. However, the effect of P3H4 in bladder cancer remains unknown. METHODS: The mRNA expression of P3H4 was measured in 44 paired tumors and adjacent normal tissues by using real-time reverse transcription-polymerase chain reaction. RNA-Seq data of 389 patients with bladder cancer were downloaded to investigate the effect of P3H4 on bladder cancer from The Cancer Genome Atlas (TCGA) project. RESULTS: P3H4 was overexpressed in bladder cancer compared with the adjacent normal tissue both in our tissue samples and TCGA samples. The mRNA expression of P3H4 was significantly related to several clinicopathological factors of bladder cancer, including age, race category, histologic grade, tumor histologic subtype, and AJCC stage. The high P3H4 expression group had a shorter overall survival (OS) than the low P3H4 expression group. Univariate Cox regression analysis showed that age, angiolymphatic invasion, lymph node metastasis, tumor histologic subtype, metastasis, AJCC stage, and P3H4 were significantly related to OS. Moreover, multivariate Cox analysis revealed that P3H4, as well as age and AJCC stage, was an independent predictor of poor OS. CONCLUSION: Given its tumorigenic role, P3H4 may serve as a promising tumor-promoting gene in bladder cancer. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12957-018-1507-2) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-6190559 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-61905592018-10-23 P3H4 is correlated with clinicopathological features and prognosis in bladder cancer Li, Wangjian Ye, Lihong Chen, Yongliang Chen, Peng World J Surg Oncol Research BACKGROUND: Genetic alterations play a significant role in the progression of bladder cancer. Identifying novel biomarkers to personalize the therapeutic regimen and evaluate the prognosis of patients with bladder cancer is vital. Prolyl 3-hydroxylase family member 4 (P3H4) is significantly involved in several types of human cancer. However, the effect of P3H4 in bladder cancer remains unknown. METHODS: The mRNA expression of P3H4 was measured in 44 paired tumors and adjacent normal tissues by using real-time reverse transcription-polymerase chain reaction. RNA-Seq data of 389 patients with bladder cancer were downloaded to investigate the effect of P3H4 on bladder cancer from The Cancer Genome Atlas (TCGA) project. RESULTS: P3H4 was overexpressed in bladder cancer compared with the adjacent normal tissue both in our tissue samples and TCGA samples. The mRNA expression of P3H4 was significantly related to several clinicopathological factors of bladder cancer, including age, race category, histologic grade, tumor histologic subtype, and AJCC stage. The high P3H4 expression group had a shorter overall survival (OS) than the low P3H4 expression group. Univariate Cox regression analysis showed that age, angiolymphatic invasion, lymph node metastasis, tumor histologic subtype, metastasis, AJCC stage, and P3H4 were significantly related to OS. Moreover, multivariate Cox analysis revealed that P3H4, as well as age and AJCC stage, was an independent predictor of poor OS. CONCLUSION: Given its tumorigenic role, P3H4 may serve as a promising tumor-promoting gene in bladder cancer. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12957-018-1507-2) contains supplementary material, which is available to authorized users. BioMed Central 2018-10-15 /pmc/articles/PMC6190559/ /pubmed/30322400 http://dx.doi.org/10.1186/s12957-018-1507-2 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Li, Wangjian Ye, Lihong Chen, Yongliang Chen, Peng P3H4 is correlated with clinicopathological features and prognosis in bladder cancer |
title | P3H4 is correlated with clinicopathological features and prognosis in bladder cancer |
title_full | P3H4 is correlated with clinicopathological features and prognosis in bladder cancer |
title_fullStr | P3H4 is correlated with clinicopathological features and prognosis in bladder cancer |
title_full_unstemmed | P3H4 is correlated with clinicopathological features and prognosis in bladder cancer |
title_short | P3H4 is correlated with clinicopathological features and prognosis in bladder cancer |
title_sort | p3h4 is correlated with clinicopathological features and prognosis in bladder cancer |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6190559/ https://www.ncbi.nlm.nih.gov/pubmed/30322400 http://dx.doi.org/10.1186/s12957-018-1507-2 |
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