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Recent advancements in the use of exosomes as drug delivery systems
Extracellular vesicles (EVs) are the substances that are released by most types of cells and have an important role in cell to cell communication. Among the most highly researched EVs are exosome. Recent studies show that exosomes derived from cells have different roles and targets. Many studies sho...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6190562/ https://www.ncbi.nlm.nih.gov/pubmed/30326899 http://dx.doi.org/10.1186/s12951-018-0403-9 |
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author | Bunggulawa, Edwin J. Wang, Wei Yin, Tieying Wang, Nan Durkan, Colm Wang, Yazhou Wang, Guixue |
author_facet | Bunggulawa, Edwin J. Wang, Wei Yin, Tieying Wang, Nan Durkan, Colm Wang, Yazhou Wang, Guixue |
author_sort | Bunggulawa, Edwin J. |
collection | PubMed |
description | Extracellular vesicles (EVs) are the substances that are released by most types of cells and have an important role in cell to cell communication. Among the most highly researched EVs are exosome. Recent studies show that exosomes derived from cells have different roles and targets. Many studies show that exosome can efficiently deliver many different kinds of cargo to the target cell. Therefore, they are often used to deliver therapeutic cargo for treatment. The exosomes that have been used include both natural ones and those that have been modified with other substances to increase the delivery ability. This article provides a review of both exosomes derived from various cells and modified exosome and their ability in delivering the many kinds of cargo to the target cell. |
format | Online Article Text |
id | pubmed-6190562 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-61905622018-10-23 Recent advancements in the use of exosomes as drug delivery systems Bunggulawa, Edwin J. Wang, Wei Yin, Tieying Wang, Nan Durkan, Colm Wang, Yazhou Wang, Guixue J Nanobiotechnology Review Extracellular vesicles (EVs) are the substances that are released by most types of cells and have an important role in cell to cell communication. Among the most highly researched EVs are exosome. Recent studies show that exosomes derived from cells have different roles and targets. Many studies show that exosome can efficiently deliver many different kinds of cargo to the target cell. Therefore, they are often used to deliver therapeutic cargo for treatment. The exosomes that have been used include both natural ones and those that have been modified with other substances to increase the delivery ability. This article provides a review of both exosomes derived from various cells and modified exosome and their ability in delivering the many kinds of cargo to the target cell. BioMed Central 2018-10-16 /pmc/articles/PMC6190562/ /pubmed/30326899 http://dx.doi.org/10.1186/s12951-018-0403-9 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Bunggulawa, Edwin J. Wang, Wei Yin, Tieying Wang, Nan Durkan, Colm Wang, Yazhou Wang, Guixue Recent advancements in the use of exosomes as drug delivery systems |
title | Recent advancements in the use of exosomes as drug delivery systems |
title_full | Recent advancements in the use of exosomes as drug delivery systems |
title_fullStr | Recent advancements in the use of exosomes as drug delivery systems |
title_full_unstemmed | Recent advancements in the use of exosomes as drug delivery systems |
title_short | Recent advancements in the use of exosomes as drug delivery systems |
title_sort | recent advancements in the use of exosomes as drug delivery systems |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6190562/ https://www.ncbi.nlm.nih.gov/pubmed/30326899 http://dx.doi.org/10.1186/s12951-018-0403-9 |
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