Cargando…
Neuropathic pain modulation after spinal cord injury by breathing-controlled electrical stimulation (BreEStim) is associated with restoration of autonomic dysfunction
BACKGROUND: Recent findings have implicated supraspinal origins from the pain neuromatrix– central autonomic network (PNM–CAN) in the generation of neuropathic pain (NP) after spinal cord injury (SCI). The aim of this study was to further investigate the theorized PNM–CAN mechanisms in persons with...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6190809/ https://www.ncbi.nlm.nih.gov/pubmed/30349358 http://dx.doi.org/10.2147/JPR.S174475 |
_version_ | 1783363625758490624 |
---|---|
author | Karri, Jay Li, Shengai Zhang, Larry Chen, Yen-Ting Stampas, Argyrios Li, Sheng |
author_facet | Karri, Jay Li, Shengai Zhang, Larry Chen, Yen-Ting Stampas, Argyrios Li, Sheng |
author_sort | Karri, Jay |
collection | PubMed |
description | BACKGROUND: Recent findings have implicated supraspinal origins from the pain neuromatrix– central autonomic network (PNM–CAN) in the generation of neuropathic pain (NP) after spinal cord injury (SCI). The aim of this study was to further investigate the theorized PNM–CAN mechanisms in persons with SCI by using a centrally directed pain intervention, provided by breathing-controlled electrical stimulation (BreEStim), to measure resultant autonomic changes measured by time and frequency domain heart rate variability (HRV) analysis. METHODS: Null and active BreEStim interventions were administered to SCI+NP subjects (n=10) in a random order. HRV data and VAS pain scores were collected at resting pre-test and 30 minutes post-test time points. Resting HRV data were also collected from SCI–NP subjects (n=11). RESULTS: SCI+NP subjects demonstrated a lower baseline HRV and parasympathetic tone, via SD of the normal-to-normal intervals (SDNN) and low frequency (LF) parameters, compared with SCI–NP subjects. However, following active BreEStim, SCI+NP subjects exhibited an increase in HRV and parasympathetic tone, most notably via pairs of successive R–R beat lengths varying by greater than 50 ms (NN50) and proportion of NN50 for total number of beats (pNN50) parameters along with lower VAS scores. Additionally, the post-test SCI+NP group was found to have a statistically comparable autonomic profile to the SCI–NP group across all HRV variables, including SDNN and LF parameters. CONCLUSION: The analgesic effects of active BreEStim in SCI+NP subjects were associated with restoration of autonomic dysfunction in this population. |
format | Online Article Text |
id | pubmed-6190809 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-61908092018-10-22 Neuropathic pain modulation after spinal cord injury by breathing-controlled electrical stimulation (BreEStim) is associated with restoration of autonomic dysfunction Karri, Jay Li, Shengai Zhang, Larry Chen, Yen-Ting Stampas, Argyrios Li, Sheng J Pain Res Original Research BACKGROUND: Recent findings have implicated supraspinal origins from the pain neuromatrix– central autonomic network (PNM–CAN) in the generation of neuropathic pain (NP) after spinal cord injury (SCI). The aim of this study was to further investigate the theorized PNM–CAN mechanisms in persons with SCI by using a centrally directed pain intervention, provided by breathing-controlled electrical stimulation (BreEStim), to measure resultant autonomic changes measured by time and frequency domain heart rate variability (HRV) analysis. METHODS: Null and active BreEStim interventions were administered to SCI+NP subjects (n=10) in a random order. HRV data and VAS pain scores were collected at resting pre-test and 30 minutes post-test time points. Resting HRV data were also collected from SCI–NP subjects (n=11). RESULTS: SCI+NP subjects demonstrated a lower baseline HRV and parasympathetic tone, via SD of the normal-to-normal intervals (SDNN) and low frequency (LF) parameters, compared with SCI–NP subjects. However, following active BreEStim, SCI+NP subjects exhibited an increase in HRV and parasympathetic tone, most notably via pairs of successive R–R beat lengths varying by greater than 50 ms (NN50) and proportion of NN50 for total number of beats (pNN50) parameters along with lower VAS scores. Additionally, the post-test SCI+NP group was found to have a statistically comparable autonomic profile to the SCI–NP group across all HRV variables, including SDNN and LF parameters. CONCLUSION: The analgesic effects of active BreEStim in SCI+NP subjects were associated with restoration of autonomic dysfunction in this population. Dove Medical Press 2018-10-12 /pmc/articles/PMC6190809/ /pubmed/30349358 http://dx.doi.org/10.2147/JPR.S174475 Text en © 2018 Karri et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Karri, Jay Li, Shengai Zhang, Larry Chen, Yen-Ting Stampas, Argyrios Li, Sheng Neuropathic pain modulation after spinal cord injury by breathing-controlled electrical stimulation (BreEStim) is associated with restoration of autonomic dysfunction |
title | Neuropathic pain modulation after spinal cord injury by breathing-controlled electrical stimulation (BreEStim) is associated with restoration of autonomic dysfunction |
title_full | Neuropathic pain modulation after spinal cord injury by breathing-controlled electrical stimulation (BreEStim) is associated with restoration of autonomic dysfunction |
title_fullStr | Neuropathic pain modulation after spinal cord injury by breathing-controlled electrical stimulation (BreEStim) is associated with restoration of autonomic dysfunction |
title_full_unstemmed | Neuropathic pain modulation after spinal cord injury by breathing-controlled electrical stimulation (BreEStim) is associated with restoration of autonomic dysfunction |
title_short | Neuropathic pain modulation after spinal cord injury by breathing-controlled electrical stimulation (BreEStim) is associated with restoration of autonomic dysfunction |
title_sort | neuropathic pain modulation after spinal cord injury by breathing-controlled electrical stimulation (breestim) is associated with restoration of autonomic dysfunction |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6190809/ https://www.ncbi.nlm.nih.gov/pubmed/30349358 http://dx.doi.org/10.2147/JPR.S174475 |
work_keys_str_mv | AT karrijay neuropathicpainmodulationafterspinalcordinjurybybreathingcontrolledelectricalstimulationbreestimisassociatedwithrestorationofautonomicdysfunction AT lishengai neuropathicpainmodulationafterspinalcordinjurybybreathingcontrolledelectricalstimulationbreestimisassociatedwithrestorationofautonomicdysfunction AT zhanglarry neuropathicpainmodulationafterspinalcordinjurybybreathingcontrolledelectricalstimulationbreestimisassociatedwithrestorationofautonomicdysfunction AT chenyenting neuropathicpainmodulationafterspinalcordinjurybybreathingcontrolledelectricalstimulationbreestimisassociatedwithrestorationofautonomicdysfunction AT stampasargyrios neuropathicpainmodulationafterspinalcordinjurybybreathingcontrolledelectricalstimulationbreestimisassociatedwithrestorationofautonomicdysfunction AT lisheng neuropathicpainmodulationafterspinalcordinjurybybreathingcontrolledelectricalstimulationbreestimisassociatedwithrestorationofautonomicdysfunction |