Parkin deficiency modulates NLRP3 inflammasome activation by attenuating an A20‐dependent negative feedback loop

Neuroinflammation and mitochondrial dysfunction, key mechanisms in the pathogenesis of Parkinson's disease (PD), are usually explored independently. Loss‐of‐function mutations of PARK2 and PARK6, encoding the E3 ubiquitin protein ligase Parkin and the mitochondrial serine/threonine kinase PINK1...

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Detalles Bibliográficos
Autores principales: Mouton‐Liger, François, Rosazza, Thibault, Sepulveda‐Diaz, Julia, Ieang, Amélie, Hassoun, Sidi‐Mohamed, Claire, Emilie, Mangone, Graziella, Brice, Alexis, Michel, Patrick P., Corvol, Jean‐Christophe, Corti, Olga
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6190839/
https://www.ncbi.nlm.nih.gov/pubmed/29665074
http://dx.doi.org/10.1002/glia.23337

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