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Update on Neutrophil Function in Severe Inflammation
Neutrophils are main players in the effector phase of the host defense against micro-organisms and have a major role in the innate immune response. Neutrophils show phenotypic heterogeneity and functional flexibility, which highlight their importance in regulation of immune function. However, neutro...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6190891/ https://www.ncbi.nlm.nih.gov/pubmed/30356867 http://dx.doi.org/10.3389/fimmu.2018.02171 |
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author | Mortaz, Esmaeil Alipoor, Shamila D. Adcock, Ian M. Mumby, Sharon Koenderman, Leo |
author_facet | Mortaz, Esmaeil Alipoor, Shamila D. Adcock, Ian M. Mumby, Sharon Koenderman, Leo |
author_sort | Mortaz, Esmaeil |
collection | PubMed |
description | Neutrophils are main players in the effector phase of the host defense against micro-organisms and have a major role in the innate immune response. Neutrophils show phenotypic heterogeneity and functional flexibility, which highlight their importance in regulation of immune function. However, neutrophils can play a dual role and besides their antimicrobial function, deregulation of neutrophils and their hyperactivity can lead to tissue damage in severe inflammation or trauma. Neutrophils also have an important role in the modulation of the immune system in response to severe injury and trauma. In this review we will provide an overview of the current understanding of neutrophil subpopulations and their function during and post-infection and discuss the possible mechanisms of immune modulation by neutrophils in severe inflammation. |
format | Online Article Text |
id | pubmed-6190891 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-61908912018-10-23 Update on Neutrophil Function in Severe Inflammation Mortaz, Esmaeil Alipoor, Shamila D. Adcock, Ian M. Mumby, Sharon Koenderman, Leo Front Immunol Immunology Neutrophils are main players in the effector phase of the host defense against micro-organisms and have a major role in the innate immune response. Neutrophils show phenotypic heterogeneity and functional flexibility, which highlight their importance in regulation of immune function. However, neutrophils can play a dual role and besides their antimicrobial function, deregulation of neutrophils and their hyperactivity can lead to tissue damage in severe inflammation or trauma. Neutrophils also have an important role in the modulation of the immune system in response to severe injury and trauma. In this review we will provide an overview of the current understanding of neutrophil subpopulations and their function during and post-infection and discuss the possible mechanisms of immune modulation by neutrophils in severe inflammation. Frontiers Media S.A. 2018-10-02 /pmc/articles/PMC6190891/ /pubmed/30356867 http://dx.doi.org/10.3389/fimmu.2018.02171 Text en Copyright © 2018 Mortaz, Alipoor, Adcock, Mumby and Koenderman. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Mortaz, Esmaeil Alipoor, Shamila D. Adcock, Ian M. Mumby, Sharon Koenderman, Leo Update on Neutrophil Function in Severe Inflammation |
title | Update on Neutrophil Function in Severe Inflammation |
title_full | Update on Neutrophil Function in Severe Inflammation |
title_fullStr | Update on Neutrophil Function in Severe Inflammation |
title_full_unstemmed | Update on Neutrophil Function in Severe Inflammation |
title_short | Update on Neutrophil Function in Severe Inflammation |
title_sort | update on neutrophil function in severe inflammation |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6190891/ https://www.ncbi.nlm.nih.gov/pubmed/30356867 http://dx.doi.org/10.3389/fimmu.2018.02171 |
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