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Genetics and sex influence peripheral and central innate immune responses and blood-brain barrier integrity

Lipopolysaccharide (LPS) is a stimulator of the innate immune system and is routinely used in animal models to study blood-brain barrier (BBB) dysfunction under inflammatory conditions. It is appreciated that both humans and mice have sexually dimorphic immune responses, which could influence the br...

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Detalles Bibliográficos
Autores principales: Erickson, Michelle A., Liang, W. Sandy, Fernandez, Elizabeth G., Bullock, Kristin M., Thysell, Jarl A., Banks, William A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191122/
https://www.ncbi.nlm.nih.gov/pubmed/30325961
http://dx.doi.org/10.1371/journal.pone.0205769