CD95/Fas ligand mRNA is toxic to cells

CD95/Fas ligand binds to the death receptor CD95 to induce apoptosis in sensitive cells. We previously reported that CD95L mRNA is enriched in sequences that, when converted to si/shRNAs, kill all cancer cells by targeting critical survival genes (Putzbach et al., 2017). We now report expression of...

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Detalles Bibliográficos
Autores principales: Putzbach, Will, Haluck-Kangas, Ashley, Gao, Quan Q, Sarshad, Aishe A, Bartom, Elizabeth T, Stults, Austin, Qadir, Abdul S, Hafner, Markus, Peter, Marcus E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191286/
https://www.ncbi.nlm.nih.gov/pubmed/30324908
http://dx.doi.org/10.7554/eLife.38621

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191286/
https://www.ncbi.nlm.nih.gov/pubmed/30324908
http://dx.doi.org/10.7554/eLife.38621

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