Characterization of Nigerian breast cancer reveals prevalent homologous recombination deficiency and aggressive molecular features

Racial/ethnic disparities in breast cancer mortality continue to widen but genomic studies rarely interrogate breast cancer in diverse populations. Through genome, exome, and RNA sequencing, we examined the molecular features of breast cancers using 194 patients from Nigeria and 1037 patients from T...

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Detalles Bibliográficos
Autores principales: Pitt, Jason J., Riester, Markus, Zheng, Yonglan, Yoshimatsu, Toshio F., Sanni, Ayodele, Oluwasola, Olayiwola, Veloso, Artur, Labrot, Emma, Wang, Shengfeng, Odetunde, Abayomi, Ademola, Adeyinka, Okedere, Babajide, Mahan, Scott, Leary, Rebecca, Macomber, Maura, Ajani, Mustapha, Johnson, Ryan S., Fitzgerald, Dominic, Grundstad, A. Jason, Tuteja, Jigyasa H., Khramtsova, Galina, Zhang, Jing, Sveen, Elisabeth, Hwang, Bryce, Clayton, Wendy, Nkwodimmah, Chibuzor, Famooto, Bisola, Obasi, Esther, Aderoju, Victor, Oludara, Mobolaji, Omodele, Folusho, Akinyele, Odunayo, Adeoye, Adewunmi, Ogundiran, Temidayo, Babalola, Chinedum, MacIsaac, Kenzie, Popoola, Abiodun, Morrissey, Michael P., Chen, Lin S., Wang, Jiebiao, Olopade, Christopher O., Falusi, Adeyinka G., Winckler, Wendy, Haase, Kerstin, Van Loo, Peter, Obafunwa, John, Papoutsakis, Dimitris, Ojengbede, Oladosu, Weber, Barbara, Ibrahim, Nasiru, White, Kevin P., Huo, Dezheng, Olopade, Olufunmilayo I., Barretina, Jordi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191428/
https://www.ncbi.nlm.nih.gov/pubmed/30327465
http://dx.doi.org/10.1038/s41467-018-06616-0

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