Cargando…

Structural basis for arginine glycosylation of host substrates by bacterial effector proteins

The bacterial effector proteins SseK and NleB glycosylate host proteins on arginine residues, leading to reduced NF-κB-dependent responses to infection. Salmonella SseK1 and SseK2 are E. coli NleB1 orthologs that behave as NleB1-like GTs, although they differ in protein substrate specificity. Here w...

Descripción completa

Detalles Bibliográficos
Autores principales:	Park, Jun Bae, Kim, Young Hun, Yoo, Youngki, Kim, Juyeon, Jun, Sung-Hoon, Cho, Jin Won, El Qaidi, Samir, Walpole, Samuel, Monaco, Serena, García-García, Ana A., Wu, Miaomiao, Hays, Michael P., Hurtado-Guerrero, Ramon, Angulo, Jesus, Hardwidge, Philip R., Shin, Jeon-Soo, Cho, Hyun-Soo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191443/ https://www.ncbi.nlm.nih.gov/pubmed/30327479 http://dx.doi.org/10.1038/s41467-018-06680-6

Ejemplares similares

NleB/SseK-catalyzed arginine-glycosylation and enteropathogen virulence are finely tuned by a single variable position contiguous to the catalytic machinery
por: García-García, Ana, et al.
Publicado: (2021)

Structural insights showing how arginine is able to be glycosylated by pathogenic effector proteins
por: Park, Jun Bae, et al.
Publicado: (2018)

Arginine glycosylation enhances methylglyoxal detoxification
por: El Qaidi, Samir, et al.
Publicado: (2021)

Arginine glycosylation regulates UDP-GlcNAc biosynthesis in Salmonella enterica
por: El Qaidi, Samir, et al.
Publicado: (2022)

Salmonella T3SS effector SseK1 arginine-glycosylates the two-component response regulator OmpR to alter bile salt resistance
por: Hasan, Md Kamrul, et al.
Publicado: (2023)

An intra-bacterial activity for a T3SS effector
por: El Qaidi, Samir, et al.
Publicado: (2020)

The T3SS Effector Protease NleC Is Active within Citrobacter rodentium
por: Hasan, Md Kamrul, et al.
Publicado: (2021)

YM155 Inhibits NleB and SseK Arginine Glycosyltransferase Activity
por: Zhu, Congrui, et al.
Publicado: (2021)

SseL Deubiquitinates RPS3 to Inhibit Its Nuclear Translocation
por: Wu, Miaomiao, et al.
Publicado: (2018)

ABC cloning: An efficient, simple, and rapid restriction/ligase-free method
por: El Qaidi, Samir, et al.
Publicado: (2019)

Hsp90 Interacts with the Bacterial Effector NleH1
por: Wu, Miaomiao, et al.
Publicado: (2018)

Catalytic DxD motif caged in Asx-turn and Met–aromatic interaction attenuates the pathogenic glycosylation of SseK2/NleB2 effectors
por: Koh, Eunhee, et al.
Publicado: (2022)

Author Correction: Catalytic DxD motif caged in Asx-turn and Met–aromatic interaction attenuates the pathogenic glycosylation of SseK2/NleB2 effectors
por: Koh, Eunhee, et al.
Publicado: (2023)

Structural Basis for EarP-Mediated Arginine Glycosylation of Translation Elongation Factor EF-P
por: Krafczyk, Ralph, et al.
Publicado: (2017)

Molecular basis for bacterial N-glycosylation by a soluble HMW1C-like N-glycosyltransferase
por: Piniello, Beatriz, et al.
Publicado: (2023)

Effectors and effects of arginine methylation
por: Wang, Yalong, et al.
Publicado: (2023)

Repurposing Avasimibe to Inhibit Bacterial Glycosyltransferases
por: Hasan, Md Kamrul, et al.
Publicado: (2022)

Bacteria-Catalyzed Arginine Glycosylation in Pathogens and Host
por: Pan, Xing, et al.
Publicado: (2020)

High-Throughput Screening for Bacterial Glycosyltransferase Inhibitors
por: El Qaidi, Samir, et al.
Publicado: (2018)

Impact of Glycosylation on Effector Functions of Therapeutic IgG †
por: Abès, Riad, et al.
Publicado: (2010)

Type III Secretion Effectors with Arginine N-Glycosyltransferase Activity
por: Araujo-Garrido, Juan Luis, et al.
Publicado: (2020)

Downregulation of PRMT1, a histone arginine methyltransferase, by sodium propionate induces cell apoptosis in colon cancer
por: Ryu, Tae Young, et al.
Publicado: (2019)

Engineered Fc-glycosylation switch to eliminate antibody effector function
por: Zhou, Qun, et al.
Publicado: (2020)

Effects of Zinc Oxide and Arginine on the Intestinal Microbiota and Immune Status of Weaned Pigs Subjected to High Ambient Temperature
por: Yoon, Se Young, et al.
Publicado: (2020)

Structural basis for SdgB- and SdgA-mediated glycosylation of staphylococcal adhesive proteins
por: Kim, Dong-Gyun, et al.
Publicado: (2021)

Structural basis for translation inhibition by the glycosylated drosocin peptide
por: Koller, Timm O., et al.
Publicado: (2023)

Arginine/Lysine Residues in the Cytoplasmic Tail Promote ER Export of Plant Glycosylation Enzymes
por: Schoberer, Jennifer, et al.
Publicado: (2009)

Systematic metabolic engineering for improvement of glycosylation efficiency in Escherichia coli
por: Pandhal, Jagroop, et al.
Publicado: (2012)

Molecular Recognition of GalNAc in Mucin-Type O-Glycosylation
por: Sanz-Martinez, Ignacio, et al.
Publicado: (2023)

Monitoring Phosphoinositide Fluxes and Effectors During Leukocyte Chemotaxis and Phagocytosis
por: Montaño-Rendón, Fernando, et al.
Publicado: (2021)

Structural basis for substrate specificity and catalysis of α1,6-fucosyltransferase
por: García-García, Ana, et al.
Publicado: (2020)

Differential impact of l-arginine deprivation on the activation and effector functions of T cells and macrophages
por: Choi, B.-S., et al.
Publicado: (2009)

Arginine GlcNAcylation and Activity Regulation of PhoP by a Type III Secretion System Effector in Salmonella
por: Xue, Juan, et al.
Publicado: (2022)

Molecular basis and diagnosis of thalassemia
por: Lee, Jee-Soo, et al.
Publicado: (2021)

Glycosylation of Glycolipids in Cancer: Basis for Development of Novel Therapeutic Approaches
por: Daniotti, Jose L., et al.
Publicado: (2013)

Glycosylating Effectors of Legionella pneumophila: Finding the Sweet Spots for Host Cell Subversion
por: Belyi, Yury, et al.
Publicado: (2022)

The Role of Protein Arginine Methyltransferases in Inflammatory Responses
por: Kim, Ji Hye, et al.
Publicado: (2016)

Detoxification of Glutaraldehyde Treated Porcine Pericardium Using L-arginine & NABH(4)
por: Kim, Kwan-Chang, et al.
Publicado: (2011)

Protein arginine methyltransferases: promising targets for cancer therapy
por: Hwang, Jee Won, et al.
Publicado: (2021)

Structural basis for Sfm1 functioning as a protein arginine methyltransferase
por: Lv, Fengjuan, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_c232m9ip3v8r30rnbakfnqkqbm