The Ambiguous Roles of Extracellular Vesicles in HIV Replication and Pathogenesis

Cells from all kingdoms of life can release membrane-enclosed vesicles to the extracellular milieu. These extracellular vesicles (EVs) may function as mediators of intercellular communication, allowing the transfer of biologically active molecules between cells and organisms. It has become clear tha...

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Detalles Bibliográficos
Autores principales: Dias, Marcos V. S., Costa, Cristina S., daSilva, Luis L. P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191503/
https://www.ncbi.nlm.nih.gov/pubmed/30364166
http://dx.doi.org/10.3389/fmicb.2018.02411
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author Dias, Marcos V. S.
Costa, Cristina S.
daSilva, Luis L. P.
author_facet Dias, Marcos V. S.
Costa, Cristina S.
daSilva, Luis L. P.
author_sort Dias, Marcos V. S.
collection PubMed
description Cells from all kingdoms of life can release membrane-enclosed vesicles to the extracellular milieu. These extracellular vesicles (EVs) may function as mediators of intercellular communication, allowing the transfer of biologically active molecules between cells and organisms. It has become clear that HIV particles and certain types of EVs, such as exosomes, share many similarities regarding morphology, composition, and biogenesis. This review presents a summary of the literature describing the intricate relationship between HIV and EVs biogenesis. Also, we discuss the latest progress toward understanding the mechanisms by which EVs influence HIV pathogenesis, as well as, how HIV modulates EVs composition in infected cells to facilitate viral spread.
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spelling pubmed-61915032018-10-24 The Ambiguous Roles of Extracellular Vesicles in HIV Replication and Pathogenesis Dias, Marcos V. S. Costa, Cristina S. daSilva, Luis L. P. Front Microbiol Microbiology Cells from all kingdoms of life can release membrane-enclosed vesicles to the extracellular milieu. These extracellular vesicles (EVs) may function as mediators of intercellular communication, allowing the transfer of biologically active molecules between cells and organisms. It has become clear that HIV particles and certain types of EVs, such as exosomes, share many similarities regarding morphology, composition, and biogenesis. This review presents a summary of the literature describing the intricate relationship between HIV and EVs biogenesis. Also, we discuss the latest progress toward understanding the mechanisms by which EVs influence HIV pathogenesis, as well as, how HIV modulates EVs composition in infected cells to facilitate viral spread. Frontiers Media S.A. 2018-10-10 /pmc/articles/PMC6191503/ /pubmed/30364166 http://dx.doi.org/10.3389/fmicb.2018.02411 Text en Copyright © 2018 Dias, Costa and daSilva. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Dias, Marcos V. S.
Costa, Cristina S.
daSilva, Luis L. P.
The Ambiguous Roles of Extracellular Vesicles in HIV Replication and Pathogenesis
title The Ambiguous Roles of Extracellular Vesicles in HIV Replication and Pathogenesis
title_full The Ambiguous Roles of Extracellular Vesicles in HIV Replication and Pathogenesis
title_fullStr The Ambiguous Roles of Extracellular Vesicles in HIV Replication and Pathogenesis
title_full_unstemmed The Ambiguous Roles of Extracellular Vesicles in HIV Replication and Pathogenesis
title_short The Ambiguous Roles of Extracellular Vesicles in HIV Replication and Pathogenesis
title_sort ambiguous roles of extracellular vesicles in hiv replication and pathogenesis
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191503/
https://www.ncbi.nlm.nih.gov/pubmed/30364166
http://dx.doi.org/10.3389/fmicb.2018.02411
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