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Herbal Bioenhancers in Veterinary Phytomedicine

Herbal bioenhancers are active phytomolecules that increase the bioavailability, bioefficacy and biological activity of various drugs when coadministered at low concentrations. These valuable compounds reduce the dose, increase the treatment rate, decrease the treatment duration, drug resistance or...

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Autores principales: Yurdakok-Dikmen, Begum, Turgut, Yagmur, Filazi, Ayhan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191517/
https://www.ncbi.nlm.nih.gov/pubmed/30364115
http://dx.doi.org/10.3389/fvets.2018.00249
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author Yurdakok-Dikmen, Begum
Turgut, Yagmur
Filazi, Ayhan
author_facet Yurdakok-Dikmen, Begum
Turgut, Yagmur
Filazi, Ayhan
author_sort Yurdakok-Dikmen, Begum
collection PubMed
description Herbal bioenhancers are active phytomolecules that increase the bioavailability, bioefficacy and biological activity of various drugs when coadministered at low concentrations. These valuable compounds reduce the dose, increase the treatment rate, decrease the treatment duration, drug resistance or related adverse reactions which have economical implications in livestock and pet medicine. Eventhough the concept of herbal bioenhancers are known for years through Ayurvedic medicine, the underlying mechanisms remains unclear. The main mechanisms involved are related to drug absorption (effect on solubility, drug efflux and transport proteins, increased permeability in gastrointestinal system) and drug metabolism (inhibition/induction of drug metabolysing enzymes, thermogenic effect). Due to species specific differences in these mechanisms, corresponding data on human and laboratory animal could not be attributed. As multidrug resistance is a major treat to both human and animal health, within “One Health” concept, efficient therapeutical strategies are encouraged by authorities, where focus on herbal supplements as a vast unexploited field remains to be researched within “Bioenhancement Concept.” This review brings insight to mechanims involved in bioenhancing effect, examples of herbal extracts and phytoactive compounds and their potential in the veterinary medicine including different classes of drugs such as antibiotics, anticancerous, antiviral, and antituberculosis.
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spelling pubmed-61915172018-10-24 Herbal Bioenhancers in Veterinary Phytomedicine Yurdakok-Dikmen, Begum Turgut, Yagmur Filazi, Ayhan Front Vet Sci Veterinary Science Herbal bioenhancers are active phytomolecules that increase the bioavailability, bioefficacy and biological activity of various drugs when coadministered at low concentrations. These valuable compounds reduce the dose, increase the treatment rate, decrease the treatment duration, drug resistance or related adverse reactions which have economical implications in livestock and pet medicine. Eventhough the concept of herbal bioenhancers are known for years through Ayurvedic medicine, the underlying mechanisms remains unclear. The main mechanisms involved are related to drug absorption (effect on solubility, drug efflux and transport proteins, increased permeability in gastrointestinal system) and drug metabolism (inhibition/induction of drug metabolysing enzymes, thermogenic effect). Due to species specific differences in these mechanisms, corresponding data on human and laboratory animal could not be attributed. As multidrug resistance is a major treat to both human and animal health, within “One Health” concept, efficient therapeutical strategies are encouraged by authorities, where focus on herbal supplements as a vast unexploited field remains to be researched within “Bioenhancement Concept.” This review brings insight to mechanims involved in bioenhancing effect, examples of herbal extracts and phytoactive compounds and their potential in the veterinary medicine including different classes of drugs such as antibiotics, anticancerous, antiviral, and antituberculosis. Frontiers Media S.A. 2018-10-10 /pmc/articles/PMC6191517/ /pubmed/30364115 http://dx.doi.org/10.3389/fvets.2018.00249 Text en Copyright © 2018 Yurdakok-Dikmen, Turgut and Filazi. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Veterinary Science
Yurdakok-Dikmen, Begum
Turgut, Yagmur
Filazi, Ayhan
Herbal Bioenhancers in Veterinary Phytomedicine
title Herbal Bioenhancers in Veterinary Phytomedicine
title_full Herbal Bioenhancers in Veterinary Phytomedicine
title_fullStr Herbal Bioenhancers in Veterinary Phytomedicine
title_full_unstemmed Herbal Bioenhancers in Veterinary Phytomedicine
title_short Herbal Bioenhancers in Veterinary Phytomedicine
title_sort herbal bioenhancers in veterinary phytomedicine
topic Veterinary Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191517/
https://www.ncbi.nlm.nih.gov/pubmed/30364115
http://dx.doi.org/10.3389/fvets.2018.00249
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