Development of Autoimmune Hepatitis during Direct-acting Antiviral Therapy for Chronic Hepatitis C Virus Infection

An 81-year-old woman developed liver dysfunction after two months' treatment with direct-acting antivirals (DAAs) for chronic hepatitis C virus (HCV) infection. She was positive for serum anti-nuclear antibody, with an elevated immunoglobulin G level. A liver biopsy revealed high-grade interfac...

Descripción completa

Detalles Bibliográficos
Autores principales: Matsumoto, Kotaro, Kikuchi, Kentaro, Kajiyama, Yusuke, Takano, Yuichi, Mabuchi, Masatoshi, Doi, Shinpei, Sato, Koichiro, Miyakawa, Hiroshi, Yasuda, Ichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191578/
https://www.ncbi.nlm.nih.gov/pubmed/29709942
http://dx.doi.org/10.2169/internalmedicine.0613-17
_version_ 1783363745955708928
author Matsumoto, Kotaro
Kikuchi, Kentaro
Kajiyama, Yusuke
Takano, Yuichi
Mabuchi, Masatoshi
Doi, Shinpei
Sato, Koichiro
Miyakawa, Hiroshi
Yasuda, Ichiro
author_facet Matsumoto, Kotaro
Kikuchi, Kentaro
Kajiyama, Yusuke
Takano, Yuichi
Mabuchi, Masatoshi
Doi, Shinpei
Sato, Koichiro
Miyakawa, Hiroshi
Yasuda, Ichiro
author_sort Matsumoto, Kotaro
collection PubMed
description An 81-year-old woman developed liver dysfunction after two months' treatment with direct-acting antivirals (DAAs) for chronic hepatitis C virus (HCV) infection. She was positive for serum anti-nuclear antibody, with an elevated immunoglobulin G level. A liver biopsy revealed high-grade interface hepatitis and infiltrate of lymphocytes and plasma cells. DAA-associated drug-induced autoimmune hepatitis (DI-AIH) was considered. Her liver dysfunction improved after discontinuing DAA therapy and starting prednisolone treatment. The differential diagnosis for AIH should include liver injury during DAA therapy for chronic HCV infection.
format Online
Article
Text
id pubmed-6191578
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher The Japanese Society of Internal Medicine
record_format MEDLINE/PubMed
spelling pubmed-61915782018-10-19 Development of Autoimmune Hepatitis during Direct-acting Antiviral Therapy for Chronic Hepatitis C Virus Infection Matsumoto, Kotaro Kikuchi, Kentaro Kajiyama, Yusuke Takano, Yuichi Mabuchi, Masatoshi Doi, Shinpei Sato, Koichiro Miyakawa, Hiroshi Yasuda, Ichiro Intern Med Case Report An 81-year-old woman developed liver dysfunction after two months' treatment with direct-acting antivirals (DAAs) for chronic hepatitis C virus (HCV) infection. She was positive for serum anti-nuclear antibody, with an elevated immunoglobulin G level. A liver biopsy revealed high-grade interface hepatitis and infiltrate of lymphocytes and plasma cells. DAA-associated drug-induced autoimmune hepatitis (DI-AIH) was considered. Her liver dysfunction improved after discontinuing DAA therapy and starting prednisolone treatment. The differential diagnosis for AIH should include liver injury during DAA therapy for chronic HCV infection. The Japanese Society of Internal Medicine 2018-04-27 2018-09-15 /pmc/articles/PMC6191578/ /pubmed/29709942 http://dx.doi.org/10.2169/internalmedicine.0613-17 Text en Copyright © 2018 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Matsumoto, Kotaro
Kikuchi, Kentaro
Kajiyama, Yusuke
Takano, Yuichi
Mabuchi, Masatoshi
Doi, Shinpei
Sato, Koichiro
Miyakawa, Hiroshi
Yasuda, Ichiro
Development of Autoimmune Hepatitis during Direct-acting Antiviral Therapy for Chronic Hepatitis C Virus Infection
title Development of Autoimmune Hepatitis during Direct-acting Antiviral Therapy for Chronic Hepatitis C Virus Infection
title_full Development of Autoimmune Hepatitis during Direct-acting Antiviral Therapy for Chronic Hepatitis C Virus Infection
title_fullStr Development of Autoimmune Hepatitis during Direct-acting Antiviral Therapy for Chronic Hepatitis C Virus Infection
title_full_unstemmed Development of Autoimmune Hepatitis during Direct-acting Antiviral Therapy for Chronic Hepatitis C Virus Infection
title_short Development of Autoimmune Hepatitis during Direct-acting Antiviral Therapy for Chronic Hepatitis C Virus Infection
title_sort development of autoimmune hepatitis during direct-acting antiviral therapy for chronic hepatitis c virus infection
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191578/
https://www.ncbi.nlm.nih.gov/pubmed/29709942
http://dx.doi.org/10.2169/internalmedicine.0613-17
work_keys_str_mv AT matsumotokotaro developmentofautoimmunehepatitisduringdirectactingantiviraltherapyforchronichepatitiscvirusinfection
AT kikuchikentaro developmentofautoimmunehepatitisduringdirectactingantiviraltherapyforchronichepatitiscvirusinfection
AT kajiyamayusuke developmentofautoimmunehepatitisduringdirectactingantiviraltherapyforchronichepatitiscvirusinfection
AT takanoyuichi developmentofautoimmunehepatitisduringdirectactingantiviraltherapyforchronichepatitiscvirusinfection
AT mabuchimasatoshi developmentofautoimmunehepatitisduringdirectactingantiviraltherapyforchronichepatitiscvirusinfection
AT doishinpei developmentofautoimmunehepatitisduringdirectactingantiviraltherapyforchronichepatitiscvirusinfection
AT satokoichiro developmentofautoimmunehepatitisduringdirectactingantiviraltherapyforchronichepatitiscvirusinfection
AT miyakawahiroshi developmentofautoimmunehepatitisduringdirectactingantiviraltherapyforchronichepatitiscvirusinfection
AT yasudaichiro developmentofautoimmunehepatitisduringdirectactingantiviraltherapyforchronichepatitiscvirusinfection

Ejemplares similares