Pulmonary Alveolar Proteinosis with Ulcerative Colitis

A 65-year-old Japanese man was referred to our hospital for the further assessment of cough and dyspnea. He had a history of ulcerative colitis for which he was receiving treatment. Chest computed tomography showed a crazy-paving pattern. His bronchoalveolar lavage fluid had a milky appearance, and...

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Detalles Bibliográficos
Autores principales: Sakamoto, Noriho, Nakashima, Shota, Ishimoto, Hiroshi, Kakugawa, Tomoyuki, Hara, Atsuko, Yura, Hirokazu, Miyamura, Takuto, Nakamichi, Seiko, Obase, Yasushi, Ishimatsu, Yuji, Mukae, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191585/
https://www.ncbi.nlm.nih.gov/pubmed/29709938
http://dx.doi.org/10.2169/internalmedicine.0555-17
Descripción
Sumario:A 65-year-old Japanese man was referred to our hospital for the further assessment of cough and dyspnea. He had a history of ulcerative colitis for which he was receiving treatment. Chest computed tomography showed a crazy-paving pattern. His bronchoalveolar lavage fluid had a milky appearance, and a transbronchial lung biopsy specimen revealed acellular periodic acid-Schiff stain-positive bodies. The serum anti-granulocyte macrophage-colony stimulating factor (GM-CSF) antibody titer was elevated. The diagnosis was autoimmune pulmonary alveolar proteinosis (PAP). There are few reports of autoimmune PAP in patients with ulcerative colitis. Some reports suggest that PAP and inflammatory bowel disease might have a common pathogenesis involving the anti-GM-CSF antibody.

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