Pulmonary Alveolar Proteinosis with Ulcerative Colitis

A 65-year-old Japanese man was referred to our hospital for the further assessment of cough and dyspnea. He had a history of ulcerative colitis for which he was receiving treatment. Chest computed tomography showed a crazy-paving pattern. His bronchoalveolar lavage fluid had a milky appearance, and...

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Autores principales: Sakamoto, Noriho, Nakashima, Shota, Ishimoto, Hiroshi, Kakugawa, Tomoyuki, Hara, Atsuko, Yura, Hirokazu, Miyamura, Takuto, Nakamichi, Seiko, Obase, Yasushi, Ishimatsu, Yuji, Mukae, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191585/
https://www.ncbi.nlm.nih.gov/pubmed/29709938
http://dx.doi.org/10.2169/internalmedicine.0555-17
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author Sakamoto, Noriho
Nakashima, Shota
Ishimoto, Hiroshi
Kakugawa, Tomoyuki
Hara, Atsuko
Yura, Hirokazu
Miyamura, Takuto
Nakamichi, Seiko
Obase, Yasushi
Ishimatsu, Yuji
Mukae, Hiroshi
author_facet Sakamoto, Noriho
Nakashima, Shota
Ishimoto, Hiroshi
Kakugawa, Tomoyuki
Hara, Atsuko
Yura, Hirokazu
Miyamura, Takuto
Nakamichi, Seiko
Obase, Yasushi
Ishimatsu, Yuji
Mukae, Hiroshi
author_sort Sakamoto, Noriho
collection PubMed
description A 65-year-old Japanese man was referred to our hospital for the further assessment of cough and dyspnea. He had a history of ulcerative colitis for which he was receiving treatment. Chest computed tomography showed a crazy-paving pattern. His bronchoalveolar lavage fluid had a milky appearance, and a transbronchial lung biopsy specimen revealed acellular periodic acid-Schiff stain-positive bodies. The serum anti-granulocyte macrophage-colony stimulating factor (GM-CSF) antibody titer was elevated. The diagnosis was autoimmune pulmonary alveolar proteinosis (PAP). There are few reports of autoimmune PAP in patients with ulcerative colitis. Some reports suggest that PAP and inflammatory bowel disease might have a common pathogenesis involving the anti-GM-CSF antibody.
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spelling pubmed-61915852018-10-19 Pulmonary Alveolar Proteinosis with Ulcerative Colitis Sakamoto, Noriho Nakashima, Shota Ishimoto, Hiroshi Kakugawa, Tomoyuki Hara, Atsuko Yura, Hirokazu Miyamura, Takuto Nakamichi, Seiko Obase, Yasushi Ishimatsu, Yuji Mukae, Hiroshi Intern Med Case Report A 65-year-old Japanese man was referred to our hospital for the further assessment of cough and dyspnea. He had a history of ulcerative colitis for which he was receiving treatment. Chest computed tomography showed a crazy-paving pattern. His bronchoalveolar lavage fluid had a milky appearance, and a transbronchial lung biopsy specimen revealed acellular periodic acid-Schiff stain-positive bodies. The serum anti-granulocyte macrophage-colony stimulating factor (GM-CSF) antibody titer was elevated. The diagnosis was autoimmune pulmonary alveolar proteinosis (PAP). There are few reports of autoimmune PAP in patients with ulcerative colitis. Some reports suggest that PAP and inflammatory bowel disease might have a common pathogenesis involving the anti-GM-CSF antibody. The Japanese Society of Internal Medicine 2018-04-27 2018-09-15 /pmc/articles/PMC6191585/ /pubmed/29709938 http://dx.doi.org/10.2169/internalmedicine.0555-17 Text en Copyright © 2018 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Sakamoto, Noriho
Nakashima, Shota
Ishimoto, Hiroshi
Kakugawa, Tomoyuki
Hara, Atsuko
Yura, Hirokazu
Miyamura, Takuto
Nakamichi, Seiko
Obase, Yasushi
Ishimatsu, Yuji
Mukae, Hiroshi
Pulmonary Alveolar Proteinosis with Ulcerative Colitis
title Pulmonary Alveolar Proteinosis with Ulcerative Colitis
title_full Pulmonary Alveolar Proteinosis with Ulcerative Colitis
title_fullStr Pulmonary Alveolar Proteinosis with Ulcerative Colitis
title_full_unstemmed Pulmonary Alveolar Proteinosis with Ulcerative Colitis
title_short Pulmonary Alveolar Proteinosis with Ulcerative Colitis
title_sort pulmonary alveolar proteinosis with ulcerative colitis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191585/
https://www.ncbi.nlm.nih.gov/pubmed/29709938
http://dx.doi.org/10.2169/internalmedicine.0555-17
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